Klevens et al characterize cases of hepatitis A disease reported from 2005 through 2007 to determine who remains at risk in the United States. Their findings suggest that, in addition to continued childhood vaccination, vaccinating susceptible travelers is likely to reduce the rate of hepatitis A disease further. The authors found an overall annual incidence rate of 1.3 per 100 000 population (range by site, 0.7-2.3). Of the reported cases, 53.4% were male, 42.4% were white, 44.7% were aged 15 to 39 years, and 91.4% resided in urban areas. Reported risk factors were international travel (45.8%), contact with a case (14.8%), employee or child in a daycare center (7.6%), exposure during a food or waterborne common-source outbreak (7.2%), illicit drug use (4.3%), and men who had sex with men (MSM) (3.9%).