Hospitals participating in CRUSADE collected data on patient demographic and clinical information, physician and hospital characteristics, medical histories, immediate use of medications within 24 hours of presentation, use and timing of invasive cardiac procedures, in-hospital outcomes, and discharge medications. Each hospital's institutional review board reviews and approves participation in CRUSADE, and because data are collected anonymously and without unique patient identifiers, informed consent is not required. Delay from symptom onset to hospital presentation was calculated from the documented date and time of symptom onset to the documented date and time of hospital arrival and was expressed as median and interquartile range (hours). Candidate factors evaluated for association with longer delay times included age; sex; race/ethnicity (categorized as white, black, Hispanic, Asian, or other/unknown); payer type (categorized as private/health maintenance organization, Medicare, Medicaid, or self-pay/none); medical history (family history of coronary artery disease, hypertension, diabetes, current smoker, hyperlipidemia, prior myocardial infarction [MI], prior percutaneous coronary intervention [PCI], prior coronary artery bypass graft surgery [CABG], prior congestive heart failure [CHF], prior stroke, renal insufficiency, CHF at presentation); body mass index (BMI) (categorized as underweight <18.5, normal 18.5 to <25, overweight 25 to <30, obese 30 to <40, or extremely obese ≥40 [calculated as weight in kilograms divided by height in meters squared]); heart rate and systolic blood pressure at presentation; electrocardiogram (ECG) findings (categorized as ST-segment depression, transient ST-segment elevation, both, or neither); time of day and day of week at presentation (weekdays were defined as Monday to Friday and included daytime from >8 AM to 4 PM, evening from >4 PM to 12 AM, and night from >12 AM to 8 AM; weekends were defined as Saturday and Sunday and included daytime from >8 AM to 4 PM, evening from >4 PM to 12 AM, and night from >12 AM to 8 AM); year of presentation; attending physician (categorized as cardiologist or noncardiologist); hospital region (West, South, Midwest, Northeast); type of hospital (no catheterization laboratory; catheterization laboratory only, no PCI; PCI only, no on-site surgery; or PCI with on-site surgery); teaching hospital; and number of hospital beds. Holidays were categorized as weekdays if they fell on Monday to Friday and weekends if they fell on Saturday or Sunday.