Aside from return of symptoms in a small number of patients as described, there were no significant adverse events reported. On the global assessment scale (n = 64), the mean (SD) score was 1.43 (0.88). No one reported significant worsening (Likert scale score, −2), and 56 (88%) reported overall improvement. Among this group, improvement was defined as significant (Likert scale score, +2) by 43 (67%). In 3 elderly patients (ages 84, 85, and 73 years) a substantial improvement of cognitive impairment was observed (increases in absolute Mini-Mental State Examination score from 14 to 24, from 14 to 23, and from 14 to 30 at 6 to 8 weeks after discontinuation of 7, 7, and 6 drugs, respectively). All of the reported 56 improvements of cognitive impairment were reported in the first couple of months following drug discontinuation and, except for 3 of 10 patients who eventually died, were maintained throughout follow-up assessments. Ten participants (14%) died during follow-up; the mean (SD) overall time until death was 13 (9) months (range, 4-33 months). The mean age of death was 89 years (range, 82-102 years). One patient with severe congestive heart failure died in hospital after 6 months of follow-up. Three died of sepsis during hospitalization (ages 87, 88, and 102 years; follow-up of 13, 18, and 6 months, respectively). Four died at home (ages 83, 91, 93, and 93 years; follow-up of 9, 11, 9, and 33 months, respectively). No deaths were considered to be related to the original indications for the drugs discontinued. Of 10 patients who died, 7 had reported improved quality of life in their last period of life. Autopsies are not routinely done in Israel and were not performed in participants who died. One woman aged 87 years who had severe vascular dementia died peacefully at home (probably of recurrent stroke) after only 4 months. The only participant younger than 70 years in whom 6 drugs had been discontinued (disothiazide, glibenclamide, theophylline, oxybutynin, betahistine, and pentoxifylline) remained normotensive and normoglycemic after drug discontinuation. He had severe comorbidity (metabolic syndrome, severe ischemic heart disease, recurrent strokes, chronic obstructive pulmonary disease, and dementia) and experienced sudden death at the age of 69 years after 22 months of follow-up.