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Editor's Correspondence | October 26, 2009

ALLHAT Findings Revisited in the Context of Subsequent Analyses, Other Trials, and Meta-analyses—Reply

Jackson T. Wright, MD, PhD; Jeffrey L. Probstfield, MD; William C. Cushman, MD; Sara Pressel, MS; Jeffrey A. Cutler, MD, MPH; Barry R. Davis, MD, PhD; Paula T. Einhorn, MD, MS; Mahboob Rahman, MD; Paul K. Whelton, MD, MSc; Charles E. Ford, PhD; L. Julian Haywood, MD; Karen L. Margolis, MD, MPH; Suzanne Oparil, MD; Henry R. Black, MD; Michael H. Alderman, MD; ALLHAT Collaborative Research Group

Arch Intern Med. 2009;169(19):1806-1818. doi:10.1001/archinternmed.2009.372.

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We appreciate the favorable comments by Dr Onuigbo on this latest ALLHAT publication.¹ We were also impressed by the very positive findings in thiazide-treated patients. ALLHAT was designed to determine whether α-blockers, ACEIs, or CCBs were superior to thiazide-type diuretics (prescribed at an appropriate dosage) as initial therapy for reduction of cardiovascular or renal outcomes.¹ While potentially understated, we believe that our overall conclusion that the thiazide-type diuretic was not surpassed is consistent with the data and trial objectives.

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Wright JT, Jr, Probstfield JL, Cushman WC, et al. ALLHAT Findings Revisited in the Context of Subsequent Analyses, Other Trials, and Meta-analyses—Reply. Arch Intern Med. 2009;169(19):1806-1818. doi:10.1001/archinternmed.2009.372.

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