Accepted for Publication: January 31, 2015.
Published Online: March 30, 2015. doi:10.1001/jamainternmed.2015.0461.
Study concept and design: Henriksen, Christensen, Bliddal.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Henriksen, Christensen, Bliddal.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Henriksen, Christensen.
Obtained funding: Henriksen, Bliddal.
Administrative, technical, or material support: Henriksen, Klokker, Bandak, Ellegaard, Boesen, Bartels, Bliddal.
Study supervision: Henriksen, Bliddal.
Conflict of Interest Disclosures: Dr Henriksen is associated with the Danish Association of Physiotherapists, which could benefit from wide uptake of this publication. Dr Christensen is involved in many health care initiatives and research that could benefit from wide uptake of this publication (including Cochrane, Outcome Measures in Rheumatology [OMERACT], and the Grading of Recommendations Assessment, Development, and Evaluation [GRADE] Working Group). No other disclosures were reported.
Funding/Support: This study was supported by grant 10-093704 from the Danish Council for Independent Research, Medical Science and by the Oak Foundation, Association of Danish Physiotherapists, Lundbeck Foundation, and Capital Region of Denmark.
Role of the Funder/Sponsor: The funding sources had no role in the study design, data collection and analysis, interpretation or reporting of this work, or the decision to submit the work for publication. All authors are independent of the funding sources.
Additional Contributions: The staff at the Department of Radiology, Copenhagen University Hospital at Bispebjerg and Frederiksberg—in particular, research technicians Janus Nybing Damm, BSc, and Rasmus Bouert, BSc—provided professional help obtaining and coordinating the acquisition of the radiographs and magnetic resonance images. The laboratory technicians Eva Andersen, BSc, Jack Olsen, BSc, and Inger Wætjen, BSc, from the Parker Institute obtained and analyzed blood samples. Study nurses Merete Wille, RN, Christine Tara Lang, RN, and Lizzie Zafirakos, RN, at the Parker Institute managed the study drugs and cared for participants during the study visits. Physical therapists Katrine Mouritsen, BSc, and Helene Clausen, BSc, at the Parker Institute assisted in providing the exercise intervention. None of these contributors received additional compensation beyond their usual salaries for their contributions.