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Editor's Correspondence |

Establishing an Optimal Therapeutic Range for Coumarins

Giuseppe Bellelli, MD; Renzo Rozzini, MD; Marco Trabucchi, MD
Arch Intern Med. 2004;164(20):2281-2283. doi:10.1001/archinte.164.20.2282-a.
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In their article recently published in the ARCHIVES, Torn and colleagues1 underscore the importance to establish an optimal therapeutic range for people taking warfarin. Warfarin, in fact, is associated with a high risk of bleeding when the international normalized ratio rises above the upper limits and with a lacking prophylactic effect when it falls under the lower limits of the therapeutic range. To encompass these problems, a strict control performed by experienced personnel in anticoagulant (AC) clinics and the use of computer-assisted dosage adjustment are recommended in the editorial by O’Donnel and Hirsh2 in the same ARCHIVES issue.

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