Gastroesophageal reflux disease (GERD) is a common chronic problem that can be treated with medication, surgery, or endoscopic techniques. To compare treatment options for GERD, researchers need a valid, reliable, and comprehensive assessment method to aid in clinical decision making, especially with the advent of new technology and medications. Existing assessment methods focus primarily on symptom assessment and do not account for the burden of treatment needed to control symptoms. In this study, Liu and colleagues developed and evaluated an instrument for measuring the impact of GERD, creating 3 separate scales: overall GERD burden, the burden of GERD-related symptoms, and the burden of GERD treatments. They found that the burden of treatment is distinct from that of symptoms and conclude that their scales are reliable, valid, and responsive measures for use in patients with GERD. In addition, their analyses highlight the importance of assessing both GERD symptom and treatment burden.