Published Online: March 2, 2015. doi:10.1001/jamainternmed.2015.13.
Study concept and design: O’Brien, Hess, Kowey, Fonarow, Piccini.
Acquisition, analysis, or interpretation of data: O’Brien, Kim, Hess, Fonarow, Piccini, Peterson.
Drafting of the manuscript: O’Brien, Kim, Hess, Kowey.
Critical revision of the manuscript for important intellectual content: O’Brien, Hess, Kowey, Fonarow, Piccini, Peterson.
Statistical analysis: O’Brien, Kim, Peterson.
Obtained funding: Piccini.
Study supervision: O’Brien, Kowey, Piccini.
Conflict of Interest Disclosures: Dr O’Brien has reported receiving research support from Janssen Pharmaceuticals Inc and serving as a consultant and on the advisory board for Modest and Portola Pharmaceuticals Inc. Dr Fonarow has reported working as a consultant or on the advisory board for Modest and Ortho-McNeil Pharmaceutical. Dr Piccini has reported receiving research support from Boston Scientific Corporation and Janssen Pharmaceuticals Inc and providing consultancies to Forest Laboratories, Janssen Pharmaceuticals Inc, and Medtronic Inc. Dr Peterson has reported receiving research support from Eli Lilly & Company and Janssen Pharmaceuticals Inc. No other disclosures were reported.
Funding/Support: The ORBIT-AF registry is sponsored by Janssen Scientific Affairs LLC, Raritan, New Jersey. This project was supported in part by cooperative agreement 1U19 HS021092 from the Agency of Healthcare Research and Quality. Drs Piccini and Peterson receive research support as principal investigators for the ORBIT-AF registry.
Role of the Funder/Sponsor: The funding source had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication. All authors reviewed and agree with the content, including the sponsor.
Additional Contributions: We acknowledge the following individuals for their important contributions to this letter: James V. Freeman, MD, Laine Thomas, PhD, Jack E. Ansell, MD, Elaine M. Hylek, MD, Paul S. Chan, MD, Alan S. Go, MD, Kenneth W. Mahaffey, MD, and Paul Chang, MD. We also thank the ORBIT-AF Registry staff and participants for their important contributions to this work. Drs Ansell, Hylek, Go, and Mahaffey are compensated for their leadership as members of the ORBIT-AF Executive Committee. Dr Chang is an employee of Janssen. None of the contributors were compensated for their review of the manuscript or provision of critical feedback to the coauthors.