0
Comments, Opinions, and Brief Case Reports |

The Numb Chin Syndrome: A Critical Sign for Primary Care Physicians

Jon M. Sweet, MD
Arch Intern Med. 2004;164(12):. doi:10.1001/archinte.164.12.1347.
Text Size: A A A
Published online

Extract

Charles Bell initially described the numb chin syndrome (NCS) in 1830. Although the syndrome is frequently described in the dental, oncology, and neurology literature, its importance as a symptom of underlying, progressing, or relapsing malignant disease remains unrecognized by most primary care physicians. Below is a case of Burkitt cell acute lymphoblastic leukemia presenting with NCS as both an initial manifestation of the disease and its subsequent relapse.

Furukawa  T Charles Bell's description of numb chin syndrome. Neurology. 1988;38331
Bar-Ziv  JSlasky  BS CT imaging of mental nerve neuropathy: the numb chin syndrome. AJR Am J Roentgenol. 1997;168371- 376
PubMed
Barrett  APBuckley  DJ Selective anesthesia of peripheral branches of the trigeminal nerve due to odontogenic infection. Oral Surg Oral Med Oral Pathol. 1986;62226- 228
PubMed
Furukawa  T Numb chin syndrome in the elderly. J Neurol Neurosurg Psychiatry. 1990;53173- 176
PubMed
Lossos  ASiegal  T Numb chin syndrome in cancer patients: etiology, response to treatment, and prognostic significance. Neurology. 1992;421181- 1184
PubMed
Bruyn  RPMBoogerd  W Numb chin syndrome. Neurology. 1993;431058
PubMed
Massey  EWMoore  JSchold  SC Mental neuropathy from systemic cancer. Neurology. 1981;311277- 1281
PubMed
Myall  RWMorton  THWorthington  P Melanoma metastatic to the mandible: report of a case. Int J Oral Surg. 1983;1256- 59
PubMed
Hogan  MCLee  ASolberg  LAThome  SD Unusual presentation of multiple myeloma with unilateral visual loss and numb chin syndrome in a young adult. Am J Hematol. 2002;7055- 59
PubMed
Klokkevold  PRMiller  DAFriedlander  AH Mental nerve neuropathy: a symptom of Waldenstrom's macroglobulinemia. Oral Surg Oral Med Oral Pathol. 1989;67689- 93
PubMed
Schaller  JLBurkland  GA Rapid and complete control of idiopathic hypereosinophilia with imatinib mesylate. Med Gen Med. September7 2001;Available at: http://www.medscape.com. Accessed March 9, 2004.
Antunes  NLGorlick  RCallaja  ELis  E Numb chin syndrome in Ewing sarcoma. J Pediatr Hematol Oncol. 2000;22521- 523
PubMed
Halachmi  SMadeb  RMadjar  SWald  MRiver  YNativ  O Numb chin syndrome as the presenting symptom of metastatic prostate carcinoma. Urology. 2000;55286
PubMed
Marinella  MA Metastatic large cell lung cancer presenting with numb chin syndrome. Respir Med. 1997;91235- 236
PubMed
Benito-Leon  JSimon  RMiera  C Numb chin syndrome as the initial manifestation of HIV infection. Neurology. 1998;50511- 512
PubMed
Maillefert  JFDardel  PPiroth  CTavernier  C Mental nerve neuropathy in Lyme disease. Rev Rhum Engl Ed. 1997;64855
PubMed
Genereau  TLortholary  OBiousse  VGuillevin  L Numb chin syndrome as first sign of temporal arteritis. J Rheumatol. 1999;261425- 1426
PubMed
Friedlander  AHGenser  LSwerdloff  M Mental nerve neuropathy: a complication of sickle-cell crisis. Oral Surg Oral Med Oral Pathol. 1980;4915- 17
PubMed
Cohen  DMReinhardt  RA Systemic sarcoidosis presenting with Horner's syndrome and mandibular paresthesia. Oral Surg Oral Med Oral Pathol. 1982;53577- 581
PubMed
Kirson  LETomaro  AJ Mental nerve paresthesia secondary to sickle cell crisis. Oral Surg Oral Med Oral Pathol. 1979;48509- 512
PubMed
De Pena  CALee  YYVan Tassel  P Lymphomatous involvement of the trigeminal nerve and Meckel cave: CT and MR appearance. AJNR Am J Neuroradiol. 1989;10S15- S17
PubMed
Marsot-Dupuch  KMatozza  FFirat  MM  et al.  Mandibular nerve: MR versus CT about 10 proved unusual tumors. Neuroradiology. 1990;32492- 496
PubMed
Burt  RKSharfman  WHKarp  BIWilson  WH Mental neuropathy (numb chin syndrome): a harbinger of tumor progression or relapse. Cancer. 1992;70877- 881
PubMed

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 15

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles
Jobs
brightcove.createExperiences();