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Review Article |

Catheter-Associated Infections:  Pathogenesis Affects Prevention FREE

Barbara W. Trautner; Rabih O. Darouiche
Arch Intern Med. 2004;164(8):842-850. doi:10.1001/archinte.164.8.842.
Text Size: A A A
Published online

Intravascular catheters and urinary catheters are the 2 most commonly inserted medical devices in the United States, and they are likewise the two most common causes of nosocomially acquired bloodstream infection. Biofilm formation on the surfaces of indwelling catheters is central to the pathogenesis of infection of both types of catheters. The cornerstone to any preventive strategy of intravascular catheter infections is strict attention to infection control practices. Antimicrobial-impregnated intravascular catheters are a useful adjunction to infection control measures. Prevention of urinary catheter–associated infection is hindered by the numbers and types of organisms present in the periurethral area as well as by the typically longer duration of catheter placement. Antimicrobial agents in general have not been effective in preventing catheter-associated urinary tract infection in persons with long-term, indwelling urethral catheters. Preventive strategies that avoid the use of antimicrobial agents may be necessary in this population.

Current medical knowledge and technology enable physicians to heal critically ill patients with diseases previously thought to be incurable. Indwelling intravascular and urinary catheters are essential components of modern medical care. Unfortunately, indwelling devices significantly increase the risk of iatrogenic infection, particularly in an already fragile patient population. Most nosocomial infections in severely ill patients are associated with the very medical devices that provide life-sustaining care. For example, a recent survey of medical intensive care units in the United States revealed that 87% of primary bloodstream infections were associated with central lines, and 95% of urinary tract infections (UTIs) were catheter associated.1 Strategies to prevent catheter-associated infections can significantly reduce morbidity, mortality, and health care costs.

This article discusses the pathogenesis and prevention of infections associated with intravascular and urinary catheters. These catheters are the 2 most commonly inserted medical devices in the United States, and they are likewise the 2 most common causes of nosocomially acquired bloodstream infection. Approximately 5 million central venous catheters are inserted per year, and of these 3% to 8% lead to bloodstream infection.2 The attributable mortality of these bloodstream infections is 12% to 25%.3 In contrast, the mortality rate of catheter-associated UTI is less than 5%. However, since the number of bladder catheters inserted each year is more than 30 million, at least 6 times higher than the number of central venous catheters, catheter-associated UTI is the second most common cause of nosocomial bloodstream infection.4,5 The organisms causing catheter-associated UTI are also a major source of resistant nosocomial pathogens.4 The differences in the pathogenesis of intravascular catheter infections and bladder catheter infections necessitate different preventive strategies.

A thorough understanding of how biofilm forms on the surfaces of indwelling catheters, whether intravascular or urinary, is central to understanding the pathogenesis of infection of these devices. A biofilm is not a static, filmy slime layer but rather is a living organism composed of multiple species of bacteria and their secreted polysaccharide matrix and components deposited from bodily fluids.68 Although we tend to think of microbes primarily in the free-floating state, in most natural environments the microorganisms associate with a surface, thus avoiding being swept away by shear forces.8

The first step in formation of catheter-associated biofilm is deposition of a conditioning film on the surface of the device. The nature of this conditioning film depends on the type of fluid that bathes the device. For example, vascular catheters rapidly acquire a sleeve of fibrin and fibronectin, while urinary catheters become encrusted with proteins, electrolytes, and other organic molecules from the host's urine.7,9 Once the catheter has acquired a conditioning film, the features of the underlying catheter surface may be partially or completely obscured. Thus, even if the bare catheter surface is inhospitable to colonization, the conditioning film may encourage microbial attachment.6 Other factors that influence attachment include hydrophobic and electrostatic forces, cell-surface structures such as pili or flagellae, and shear stress from the fluid environment.7,1012

Attached, or sessile, organisms divide to form microcolonies and then begin to secrete the extracellular polysaccharide matrix that forms the architectural structure of the biofilm. Ultimately, the organisms and their 3-dimensional matrix form thick pillars separated by fluid-filled spaces.13 The pillars can be thought of as apartment buildings, and the fluid-filled spaces are the streets between the buildings through which the organisms receive nutrients, diffuse away wastes, and send chemical signals to each other.11 Other species of bacteria may move into the biofilm, and interactions between the species can produce different microenvironments within a given biofilm.8 Under unfavorable environmental conditions, such as exhaustion of nutrients or overcrowding, sessile organisms can detach and become free-floating, or planktonic.8 The presence of planktonic organisms in the bloodstream or urine can lead in turn to symptomatic host infection.

Biofilms have major medical significance for 2 main reasons: (1) biofilms decrease susceptibility to antimicrobial agents, and (2) microbiology laboratory results based on planktonic organisms may not apply to sessile organisms embedded within a biofilm. The decreased susceptibility to microbial agents within a biofilm arises from multiple factors, including physical impairment of diffusion of antimicrobial agents, reduced bacterial growth rates, and local alterations of the microenvironment that may impair activity of the antimicrobial agent.11,14 Furthermore, the proximity of cells within a biofilm can facilitate plasmid exchange and hence enhance the spread of antimicrobial resistance.8 A common problem in clinical settings is that microbiology laboratory results are misleading because they are based on pure cultures derived from free-floating organisms. First, more species may be present in the biofilm than are reflected by the pure culture results. Second, in many cases the susceptibilities of the biofilm-associated organisms may be hundreds of times higher than those of the planktonic organisms. Since abiotic surfaces, such as those of catheters, lack the intrinsic defenses present in host tissues, antibiotics frequently are not able to clear resistant bacterial biofilms from catheter surfaces.15 Thus, even well-chosen treatment based upon laboratory results often merely suppresses a catheter-related infection until biofilm-associated organisms resurge and cause another clinical infection.

Pathogenesis of Infection

The organisms that colonize an intravascular device and subsequently disseminate into the bloodstream, causing bloodstream infection, can gain access to the device through 4 different routes: (1) invasion of the skin insertion site, (2) contamination of the catheter hub, (3) hematogenous spread from a distant site of infection, or (4) infusion of contaminated fluid through the device.16,17 The first 2 sources of infection are by far the most important. The skin site and the catheter hub can become contaminated by the patient's endogenous skin flora and by exogenous flora carried on health care workers' hands.17 While organisms that gain access through the skin insertion site tend to migrate along the external surface of the catheter, organisms inoculated into the hub migrate along the internal lumen of the catheter. The characteristic flora migrating to the catheter surface from the skin site include coagulase-negative staphylococci and Staphylococcus aureus, while nosocomial pathogens, such as Stenotrophomonas, Pseudomonas, enterococci, and Candida, as well as staphylococci, can reach the hub site via the hands of health care personnel.18

In contrast to the skin site flora and hub contaminants, hematogenously spread flora from a distant site, such as the urinary tract, are more of a theoretical than a probable source of catheter infection. Since hematogenous seeding of catheters occurs rarely, a catheter need not be removed in the presence of a bloodstream infection from a well-documented secondary source.16,19 Although epidemics of infusate-related sepsis do occur, these cases are very rare in comparison with the numbers of cases of bacteremia arising from primary catheter infection.16 The pathogenesis of infusate-related bacteremia, eg, contamination of parenteral nutrition and lipid solutions during preparation, also differs significantly from primary catheter-associated infection and will not be discussed further in this article.

Direct examination of vascular catheters using electron microscopy reveals that biofilm-embedded bacteria are found on catheters within the first 24 hours after insertion.20 However, the distribution of the biofilm is related to the duration of catheter placement. External surface colonization, probably originating from the skin, predominates in short-term catheters that have been in place less than 10 days, such as peripheral intravenous (IV) lines, noncuffed and nontunneled central venous catheters, and arterial catheters. Intraluminal colonization due to hub contamination increases progressively with time, and intraluminal colonization becomes predominant after 30 days of placement of long-term devices, such as tunneled central venous catheters, peripherally inserted central catheters (PICC lines), and subcutaneous ports.21 These differences in pathogenesis for short-term vs long-term intravascular device–related infections affect the selection of preventive strategies. Whether or not catheter colonization progresses to symptomatic bloodstream infection is probably a quantitative phenomenon, as the number of organisms recovered from a catheter surface by the roll-plate method clearly correlates with the probability of catheter-related septicemia.22

To summarize, the pathogenesis of infections of intravascular devices is a multifaceted interaction. Bacterial factors, such as the predilection of S aureus to bind to host tissue ligands, and device factors, such as the surface properties of the device material, all play a role. The factor that probably carries the most weight in terms of whether an intravascular device infection arises is the virulence properties of the colonizing organisms. However, the factors that we as health care providers may influence the most are the properties of the device itself.2

Prevention of Infections

In recent years considerable progress has been made in the area of prevention of intravascular device infection. Economic issues have driven some of this progress, as each episode of catheter-associated bloodstream infection may incur more than $25 000 in additional hospital expenditures.23 However, the fact that the pathogenesis of intravascular device infections is amenable to intervention at many steps has also spurred the development of novel preventive approaches. These novel approaches can be divided into 3 categories based on the level of supporting evidence: (1) what works, (2) what probably works, and (3) what might work (Table 1). At the top of the list of "what works" is probably the least "novel" of the novel technologies—risk factor modification. In other words, application of basic principles of infection control is currently the most effective preventive measure for intravascular device infections.24 However, the antimicrobial-impregnated catheters, which are a relatively recent innovation, also have proven efficacy in preventing intravascular device infections in appropriate patient populations. The "what probably works" category includes antimicrobial catheter flushes and prevention of thrombus formation; these promising strategies are supported by clinical data but need further study. Finally, the "what might work" category includes novel ideas that bear investigation in a clinical setting—antimicrobial hubs, active iontophoresis, and novel catheter securement devices.25

Table Graphic Jump LocationTable 1. Categories of Preventive Strategies

Risk factor modification is probably the least glamorous yet most effective strategy to prevent intravascular device infections. Risk factors fall into 3 general categories: (1) patient-related risk factors, (2) device-related risk factors, and (3) risk factors pertaining to catheter insertion and care. While patient-related risk factors such as immunosuppression or extremes of age26 are not generally subject to modification, the other categories permit considerable risk reduction.

Device-related risk factors include the number of lumens, the location of the catheter, and the duration of placement. Nonrandomized clinical trials have suggested that multilumen catheters are associated with a higher risk of infection than single-lumen catheters, probably because more ports increase the frequency of catheter manipulation.27,28 Another discretionary factor in catheter placement that affects the risk of infection is the insertion site. A recent, randomized trial comparing femoral and subclavian sites for venous catheterization found a higher rate of infectious and thrombotic complications at the femoral site. The rates of overall and major mechanical complications were similar in the 2 groups.29 Although the internal jugular site was not evaluated in this study, nonrandomized studies have found a higher rate of infectious complications at the internal jugular site than at the subclavian site.30 For peripheral IV lines, lower extremity sites are associated with a higher risk of infection than are upper extremity sites and should be avoided if possible.3,31 Finally, the best way to prevent a catheter from becoming infected is to take it out; physicians should be aggressive about removing intravascular catheters as soon as the device is no longer essential to patient care.3

Considerable progress has been made in elucidating the factors in catheter insertion and maintenance that most effectively reduce the risk of infection. Well-designed, prospective trials provide strong evidence for the use of maximal sterile barriers during catheter insertion.32 In a prospective, randomized trial comparing standard insertion techniques (sterile gloves and small drape) vs maximal sterile barriers (mask, cap, sterile gloves, gown, large drape) for placement of nontunneled central venous catheters, the rate of catheter-related septicemia was 6.3 times higher in the standard barriers group. Additionally, 67% of the infections in the standard barriers group occurred during the first 2 months after catheter insertion, while only 25%, or 1 of 4, of the infections in the maximal barriers groups occurred in the first 2 months.32 These findings suggest that the early infections probably originated in touch contamination of the guidewire or catheter at the time of insertion, while the later infections probably arose through hub contamination with extended use of the catheter.33 However, as anyone who has used maximal sterile barriers can attest, the process of assembling and donning the required items is a bit cumbersome, particularly for harried house staff. Educating physicians about the infection control advantages of maximal sterile barriers can provide them with the necessary impetus for using this technique, and can decrease the rate of catheter-related infection.34

Other technical issues pertaining to catheter insertion and care that can reduce the rate of infection basically fall under the heading of "know and respect your catheters." For example, 2% chlorhexidine is the preferred skin disinfectant for both catheter insertion and maintenance.35 Numerous studies have documented a decrease in catheter-associated infections when catheter insertion and care is provided by a designated IV therapy team rather than by house staff.3,36 Along similar lines, catheters placed outside of the hospital or under emergent conditions may easily have been contaminated during insertion and should be replaced as soon as possible.3 Once placed, catheters should be manipulated as little as possible; for example, hemodialysis catheters should be used only for hemodialysis.3 Finally, as always, hand washing is the cornerstone of infection control and should be practiced before and after inserting, replacing, accessing, or dressing an intravascular catheter.3 Although many of these recommendations are inconvenient, even annoying, for clinicians to follow on a daily basis, in the long run these simple preventive measures can markedly reduce the rate of intravascular catheter–associated infections.

Antimicrobial-impregnated central venous catheters are an effective adjunct to proper catheter insertion and care in the battle against catheter-associated infections. The premise of antimicrobial-impregnated catheters is that modifying the catheter surface to prevent attachment and biofilm formation by microorganisms will likewise prevent catheter-associated infection. The 2 types of antimicrobial-impregnated central venous catheters that have been studied the most thoroughly are the chlorhexidine/silver sulfadiazine–impregnated catheters and the minocycline/rifampin–impregnated catheters.

The chlorhexidine/silver sulfadiazine–impregnated catheters have been available for approximately 10 years, and a recent meta-analysis confirmed their effectiveness.37 In this analysis, the impregnated catheters reduced the risk of catheter-associated bloodstream infection by about 40% when used for less than 14 days in patients who were at high risk for catheter-related bloodstream infection (in an intensive care unit, immunosuppressed, or receiving total parenteral nutrition). Although a chlorhexidine/silver sulfadiazine–impregnated catheter costs approximately $25 more than a standard catheter, cost-benefit analysis favors the use of the antimicrobial-coated catheters because the potential savings accrued by averting catheter-associated bloodstream infections are substantial.38 Unfortunately, cases of anaphylactic reactions to these catheters have been reported. In Japan, chlorhexidine-containing central venous catheters were withdrawn from the market in 1997 after 13 Japanese patients experienced immediate hypersensitivity reactions to these catheters.39,40 No anaphylactoid reactions have been reported in the United States, where more than 2.5 million of these catheters have been sold so far.40

While the catheters studied in these trials had chlorhexidine/silver sulfadiazine only on the external surface, minocycline/rifampin–impregnated catheters provide antimicrobial activity on both the external and the internal surfaces.41 Head-to-head comparison of these 2 types of catheters in a prospective, randomized clinical trial in adults at high risk for catheter-related infection found a significant advantage to using the minocycline/rifampin–impregnated catheters.41 The rate of bloodstream infection with the minocycline/rifampin–impregnated catheters was 0.3% (1 of 356), while the rate of bloodstream infection with the chlorhexidine/silver sulfadiazine–impregnated catheters was 3.4% (13 of 382, P<.002). One of the most interesting aspects of these results is that 11 of the 13 bloodstream infections in the chlorhexidine/silver sulfadiazine group occurred when the catheters had been in place for more than 7 days. This finding implies that intraluminal colonization becomes increasingly important in the pathogenesis of catheter-associated infection with increasing time of placement, and the chlorhexidine/silver sulfadiazine–impregnated catheters may have lost their protective ability because they were impregnated only on the external surface. A second-generation catheter is now available that has chlorhexidine on the internal lumen as well as the combined antimicrobials on the outer surface. The amount of chlorhexidine and the extended release activity of the surface antiseptics have also been increased.42 A new trial comparing the second-generation chlorhexidine/silver sulfadiazine–impregnated catheters with the minocycline/rifampin–impregnated catheters would be useful.

Both the chlorhexidine/silver sulfadiazine– and the minocycline/rifampin–impregnated catheters are approved by the Food and Drug Administration and are currently available for use in the United States. According to recent guidelines from the Centers for Disease Control and Prevention (CDC), the use of an antimicrobial-impregnated central venous catheter is a Category IB recommendation for adults whose catheter is expected to stay in place more than 5 days if the institutional rate of catheter-related bloodstream infection is above benchmark rates despite implementation of a comprehensive infection control strategy.3 This strategy should include educating health care providers, implementing maximal sterile barrier precautions, and using 2% chlorhexidine skin preparation prior to catheter insertion.

Whether or not widespread use of antimicrobial catheters will induce bacterial resistance is an open question, although no resistant flora have been recovered from these catheters in clinical trials to date.41,43,44 Several factors may explain why resistant flora have not yet been found. First, these catheters are impregnated with 2 antimicrobial agents that have different mechanisms of activity, thus reducing the likelihood of the emergence of resistance. Indeed, the combination of minocycline and rifampin has been shown to be synergistic in preventing the colonization of catheter surfaces.43 Second, the immediate environment of an antimicrobial–impregnated vascular catheter has a high concentration of antimicrobial agents and a low density of organisms. Specifically, in the clinical trial comparing the chlorhexidine/silver sulfadiazine–impregnated catheters to the minocycline/rifampin–impregnated catheters, fewer than 25% of the catheters in either arm of the trial had any detectable colonization.41 This clinical scenario favors the eradication of organisms rather than the development of resistance. Since antimicrobial–impregnated catheters do not cause detectable systemic levels of antimicrobial agents,45 bacteria residing at distant sites are not exposed to these agents and are thus not under selection pressure to develop resistance. In any case, silver sulfadiazine, chlorhexidine, minocycline, and rifampin are not the drugs of choice to treat catheter-associated infections, and there is little cross-resistance between these agents and first-line agents for catheter-associated infections, such as vancomycin. Therefore, it is unlikely that expanded use of antimicrobial-impregnated catheters will be associated with emergence of clinically significant resistance to therapeutic agents. If the appropriate use of antimicrobial-impregnated catheters decreases the number of catheter-associated infections, the use of systemic antibiotics might decrease as well.43 However, continued surveillance for resistance as these impregnated catheters are used more widely will provide valuable insights into these issues.

Several other techniques to prevent intravascular catheter–associated infections are currently being developed. The theory behind the antibiotic lock technique, or leaving an antibiotic solution in the catheter lumen for several hours at a time, is to avoid the use of systemic antibiotics while delivering a high concentration of antibiotics to the catheter-associated pathogens. For example, use of minocycline and ethylenediaminetetraacetate (the anticoagulant EDTA) catheter flushes in 3 adults who had cumulatively had 40 intravascular catheter-related infections eliminated all such infections in 17 months of subsequent observation.46 Currently, the CDC recommends antibiotic lock solutions only in situations such as these, when the patient has had recurrent catheter-associated infections and still requires an intravascular device.3 Use of an anticoagulant alone may also be beneficial, perhaps by inhibiting formation of the fibrin sheath to which the colonizing bacteria bind. One small study in 32 patients found that heparinized catheters had lower rates of colonization and associated bloodstream infection than control catheters,9 but data are insufficient to make a widespread recommendation about surface heparinization or anticoagulation in general as a means to prevent catheter-associated infection. Other novel technologies aimed at preventing catheter-associated infection by impeding catheter colonization include antimicrobial-containing catheter hubs,47 novel securement devices that limit the in-and-out motion of the catheter at the skin site,25 and active iontophoresis, or passing a low electrical current through a silver catheter to elute inhibitory silver ions.48 These promising technologies await evaluation in full-scale clinical trials.

To summarize the techniques for preventing intravascular catheter–associated infections, the cornerstone of preventive strategies is infection control. Good hand hygiene, the use of maximal sterile barriers for insertion of central venous catheters, and specialized IV teams for catheter insertion and maintenance have all shown unequivocal benefits.3 The antimicrobial-impregnated catheters are a useful adjunct to these infection control measures. However, in clinical practice compliance with even these basic recommendations is low. A survey of 53 hospitals published in 2000 revealed that only 19% had a designated IV team, although establishing a designated IV team was at the time a category IB recommendation and has since been raised to category IA.49 Obviously, before we seek novel technology to prevent intravascular catheter–associated infections, we should take the time to read and implement established recommendations.

Pathogenesis of Infection

Progress in the area of prevention of urinary catheter–associated infections is very limited compared with that in the vascular arena. Comparing and contrasting the pathogenesis of urinary catheter–associated infections to vascular catheter–associated infections elucidates the obstacles to prevention of catheter-associated UTI (CAUTI) (Table 2). While blood deposits thrombus on catheters, urine deposits organic molecules such as Tamm-Horsfall glycoprotein, a slimy protein of renal origin. The host proteins deposited from urine may facilitate attachment to the catheter by uropathogens, for Escherichia coli and related gram-negative organisms have hairlike projections that bind to the Tamm-Horsfall protein.5052 In the bloodstream, flow at the catheter tip is rapid, whereas in a catheterized urinary tract some stasis is usually present. Stasis, of course, predisposes to high levels of bacterial colonization. Additionally, while an intravascular catheter must pass through a skin wound, urinary catheters pass through a natural orifice. Thus, implementing sterile urinary catheter insertion techniques probably plays a lesser role in prevention of CAUTI, particularly in the case of long-term urinary catheters. In contrast to the relatively low numbers of skin flora present at the insertion site of a vascular catheter, contamination of the periurethral area with high numbers of bowel flora is very common.53,54 The most frequent causative agents of nosocomial CAUTI derive from the patient's colonic flora or from the hands of health care personnel; these organisms include E coli, enterococci, Pseudomonas, Klebsiella, Enterobacter, or Candida.4 The enteric gram-negative organisms found in the catheterized urinary tract are those that are commonly associated with multidrug resistance.4 Although most intravascular catheters remain in place for days to weeks, many patients wear indwelling urinary catheters for years, even for the duration of their lives. Thus, the difficulties of preventing CAUTI are compounded by catheter location, duration of catheter placement, numbers of organisms, and types of organisms typically contaminating the catheterized urinary tract.

Table Graphic Jump LocationTable 2. Differences in Pathogenesis of Infection of Vascular and Urinary Catheters

As with vascular catheters, urinary catheters can become colonized through several routes. Extraluminal colonization may occur by direct inoculation when the catheter is inserted, or it may occur later by organisms ascending in the mucus film between the catheter and the urethra. Intraluminal colonization occurs by reflux of organisms from a contaminated drainage bag or by a break in the closed drainage system.55 Once organisms gain access to the catheterized urinary tract, the level of bacteriuria usually increases to more than 105 cfu/mL within 24 to 48 hours in the absence of antimicrobial therapy.56 Apparently the presence of the urinary catheter alters the physiology of the urinary tract and predisposes the individual to infection, because studies in healthy, noncatheterized women show that introduction of organisms into the bladder rarely leads to high-level bacteriuria.56 However, in the presence of an indwelling urethral catheter, the rate of acquisition of high-level bacteriuria is approximately 5% per day.57 Of note, bacteriuria, or the presence of bacteria in the urine, is frequently asymptomatic and is not synonymous with symptomatic UTI.

In the normal, noncatheterized bladder, the 2 main host defense mechanisms against UTI are mechanical clearance of organisms by voiding and the intrinsic antibacterial activity of the bladder wall itself.58 Proposed mechanisms for the increased risk of bacteriuria in catheterized individuals include the presence of residual urine in the bladder,5961 ischemic damage to the bladder mucosa through overdistention,62 mechanical irritation from the presence of the catheter, and the presence of a foreign body to support biofilm formation.15 Not surprisingly, a systematic evaluation of urine specimens from chronically catheterized patients revealed that 98% of weekly urine specimens from such patients contained more than 105 cfu/mL of bacteria, and over 77% of the specimens were polymicrobial.63 All of these mechanisms involved in the pathogenesis of colonization and infection of the colonized urinary tract combine to make CAUTI very difficult to prevent in individuals wearing urinary catheters for longer than 2 weeks.

Prevention of Infections

Few effective preventive strategies are available for prevention of CAUTI, and what preventive strategies exist are chiefly applicable to patients with temporary urinary catheters. As with vascular catheters, preventive strategies for CAUTI can be divided into categories such as "what works" and "what might work," but by far the largest category is "what does not work" (Table 1). The category of "what does not work" includes almost all preventive strategies utilizing antimicrobial agents or antibiotics in persons with long-term, indwelling urethral catheters. Numerous trials of oral antibiotics and urinary acidifying agents,6468 antimicrobial bladder washes,69,70 antimicrobial drainage bag solutions,71 and topical disinfectants7275 all point to the same conclusion: bacteriuria and UTI can be suppressed temporarily, but resistant flora eventually appear. For example, frequent use of the antiseptic agent chlorhexidine in a particular hospital for perineal cleaning, catheter lubrication, and drainage bag cleaning led to an outbreak in which more than 90 patients became colonized with chlorhexidine-resistant bacteria.76 The reasons for the inevitable failure to suppress bacteriuria in chronically catheterized individuals are directly related to the pathogenesis of bladder infections in these individuals: the nearby bowel flora are numerous, diverse, and frequently resistant to one or more antimicrobial agents. The catheter provides a route for organisms to enter the bladder and also serves as a foreign body for colonization. Opportunities for the exchange of DNA encoding drug resistance abound. Thus, trying to rid the catheterized bladder of all microbial flora is futile and promotes the growth of resistant organisms. Furthermore, frequent courses of antibiotics subject patients to possible adverse drug effects and suprainfections, such as Clostridium difficile colitis.77

In terms of "what works" to prevent CAUTI, the situation parallels that with vascular catheter infections in that the simplest strategies are the most effective. Use of a closed drainage system, or catheter drainage into a connected bag rather than into an open container, reduces the incidence of bacteriuria to approximately 50% at 14 days of continuous catheterization.78 This finding contrasts favorably with the documentation of significant bacteriuria in 95% of patients receiving open catheter drainage for 96 hours.79 Another very effective strategy is to avoid prolonged catheterization, or even to avoid catheterization at all. Clean, nonsterile, intermittent catheterization can lead to bladder colonization rates as low as 20% to 40% over more than a year of follow-up.80 Although randomized comparisons are lacking, the rates of bacteriuria and UTI are lower with suprapubic catheterization, condom catheters, and intermittent catheterization than with chronic indwelling urethral catheters.57,81 Some argue very convincingly that indwelling catheters are a form of "one-point restraint" for hospitalized patients, and their use should be curtailed.82 Finally, effort should be made to ensure dependent drainage at all times, because having the drainage tube above the level of the bladder or below the level of the collection bag is associated with an increased risk of CAUTI.4

In contrast to the scenario with vascular catheters, antimicrobial-impregnated urinary catheters fit best into the "what probably works" category. Most research in this area has studied silver-coated urinary catheters, but unfortunately most of these studies used bacteriuria rather than symptomatic UTI as a surrogate end point. Thus, meta-analysis of 8 trials of silver-coated urinary catheters found that the summary odds ratio for bacteriuria with use of silver-coated catheters was 0.59 (95% confidence interval, 0.42-0.84).83 However, the studies differed in important aspects of their designs (use of systemic antibiotics, patient populations), and their odds ratios also had significant heterogeneity. Examination of the single study performed in patients with acute spinal cord injury, who receive long-term urinary catheters, showed that the silver-coated catheters delayed but did not prevent the onset of bacteriuria.84 Minocycline/rifampin–impregnated urinary catheters have been demonstrated to delay the onset of gram-positive but not gram-negative bacteriuria.85 Since minocycline and rifampin are less active against gram-negative organisms, the higher numbers of gram-negative organisms at the urethral meatus than on the skin at the site of vascular catheter insertion may have overwhelmed the gram-negative antibacterial activity of these bladder catheters. Nitrofurazone-containing urinary catheters have been effective in vitro against multidrug-resistant strains of bacteria, and a single clinical trial found a lower rate of bacteriuria in patients who received nitrofurazone-impregnated urinary catheters compared with a control group.86,87 In general, antimicrobial-coated urinary catheters may offer significant benefit for hospitalized patients undergoing short-term bladder colonization, but a firm recommendation cannot yet be made for their use. A problem common to all antimicrobial-impregnated urinary catheters is that elution of subinhibitory levels of the antimicrobial agent into the urine may induce resistance in the resident organisms with prolonged catheter use.76

Although systemic antibiotics are not recommended in general for patients with asymptomatic bacteriuria, in certain situations treatment of asymptomatic bacteriuria is warranted. Treatment of asymptomatic bacteriuria in pregnant women is recommended because the incidence of preterm labor, symptomatic UTI, and pyelonephritis is higher in bacteriuric pregnant women, but whether treating the bacteriuria improves the outcome of pregnancy is unclear.88 Men with bacteriuria who are about to undergo urologic surgery should be treated to reduce the risk of postoperative bacteremia.57,89 Since postoperative UTI is very common in renal transplant patients and is a frequent source of bacteremia, asymptomatic bacteriuria should be treated in recent renal transplant patients as well.89

However, in other immunocompetent populations, treatment of asymptomatic bacteria is not recommended and might even be harmful. For example, a recent study of antimicrobial treatment of diabetic women with asymptomatic bacteriuria found no difference in the incidence of symptomatic UTI or episodes of hospitalization for UTI between the treated and untreated groups.90 However, treated women did experience significantly more treatment-related adverse effects. These findings mirror those of an earlier study of girls with asymptomatic bacteriuria, in which effective treatment of the organisms the girls had in their bladders increased their subsequent risk of contracting acute pyelonephritis with a different strain.91 Other studies support nontreatment of asymptomatic bacteriuria in institutionalized elderly persons,90 persons with spinal cord injury,65 and healthy nonpregnant women.92 Thus, screening for the presence of asymptomatic bacteriuria as well as treatment of asymptomatic bacteriuria in catheterized patients should be discouraged.

Bacterial interference is one of the leading contenders in the category of "what might work" to prevent CAUTI. Bacterial interference, or the use of benign bacteria to prevent colonization and symptomatic infection with pathogenic organisms, avoids the use of antimicrobial agents and the attendant potential problems of resistance. Deliberate vaginal colonization with Lactobacillus of women who had recurrent, non–catheter-associated UTI reduced the prevalence of vaginal coliforms and symptomatic UTI.9395 However, Lactobacillus colonizes the female urogenital epithelium but not the bladder, and thus it is not an ideal agent to prevent CAUTI. On the other hand, E coli 83972, a nonpathogenic strain, does readily colonize the abnormal urinary tracts of persons with neurogenic bladders.96 Deliberate inoculation of the bladders of persons with spinal cord injury with this strain of E coli reduced the incidence of symptomatic UTI in comparison with the patients' baseline rates of UTI.97 Furthermore, in vitro data suggest that E coli 83972–coated bladder catheters impede catheter colonization by uropathogens.98 A prospective trial of direct bladder inoculation with E coli 83972 in spinal cord–injured patients is under way.

Considerable progress has been made in the prevention of intravascular catheter–associated infections. Recent studies have brought better understanding of the risk factors for intravascular catheter infections, have clarified preventive infection control strategies, and have introduced novel technologies such as antimicrobial-impregnated vascular catheters. While vascular catheters are a relatively new phenomenon in the medical field, urinary catheters have been in use for more than a century. Recent years have not contributed substantially to our ability to prevent CAUTI, as the closed drainage system developed in 192878 is still the most effective strategy available. Unfortunately, many aspects of the pathogenesis of CAUTI render the preventive strategies that work well with vascular catheters ineffective in the bladder. However, these difficulties should not discourage research in this area but rather should be regarded as a challenge for the future.

Corresponding author and reprints: Barbara W. Trautner, MD, Spinal Cord Injury (128), Veterans Affairs Medical Center, 2002 Holcombe Blvd, Houston, TX 77030 (e-mail: trautner@bcm.tmc.edu).

Accepted for publication May 13, 2003.

This project was supported by grant HD42014 from the US Public Health Service, Washington, DC.

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Maki  DTambyah  P Engineering out the risk of infection with urinary catheters. Emerg Infect Dis. 2001;71- 13
PubMed Link to Article
Saint  S Clinical and economic consequences of nosocomial catheter-related bacteriuria. Am J Infect Control. 2000;2868- 75
PubMed Link to Article
Habash  MReid  G Microbial biofilms: their development and significance for medical-device related infections. J Clin Pharmacol. 1999;39887
PubMed Link to Article
Destedt  JWollin  TReid  G Biomaterials used in urology: current issues of biocompatibility, infection, and encrustation. J Endourol. 1998;12493- 500
PubMed Link to Article
Watnick  PKolter  R Biofilm, city of microbes. J Bacteriol. 2000;1822675- 2679
PubMed Link to Article
Appelgren  PRansjo  UBindslev  LEspersen  FLarm  O Surface heparinization of central venous catheters reduces microbial colonization in vitro and in vivo: results from a prospective, randomized trial. Crit Care Med. 1996;241482- 1489
PubMed Link to Article
Schembri  MKlemm  P Biofilm formation in a hydrodynamic environment by novel FimH variants and ramifications for virulence. Infect Immun. 2001;691322- 1328
PubMed Link to Article
Donlan  R Biofilm formation: a clinically relevant microbiological process. Clin Infect Dis. 2001;331387- 1392
PubMed Link to Article
Thomas  WTrintchina  EForero  MVogel  VSokurenko  E Bacterial adhesion to target cells enhanced by shear force. Cell. 2002;109913- 923
PubMed Link to Article
Davies  DParsek  MPearson  JIglewski  BCosterton  JGreenberg  E The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science. 1998;280295- 298
PubMed Link to Article
Costerton  JStewart  PGreenberg  E Bacterial biofilms: a common cause of persistent infections. Science. 1999;2841318- 1322
PubMed Link to Article
Nickel  JCosteron  JMcLean  ROlson  M Bacterial biofilms: influence on the pathogenesis, diagnosis and treatment of urinary tract infections. J Antimicrob Chemother. 1994;3331- 41
PubMed Link to Article
Raad  IBodey  G Infectious complications of indwelling vascular catheters. Clin Infect Dis. 1992;15197- 210
PubMed Link to Article
Crinch  CMaki  D The promise of novel technology for the prevention of intravascular device-related bloodstream infection, I: pathogenesis and short-term devices. Clin Infect Dis. 2002;341232- 1242
PubMed Link to Article
Raad  IHanna  H Intravascular catheter-related infections. Arch Intern Med. 2002;162871- 878
PubMed Link to Article
Anaissie  ESamonis  GKontoyiannis  D  et al.  Role of catheter colonization and infrequent hematogenous seeding in catheter-related infections. Eur J Clin Microbiol Infect Dis. 1995;14134- 137
PubMed Link to Article
Passerini  LLan  KCosterton  JKing  E Biofilms on indwelling vascular catheters. Crit Care Med. 1992;20665- 673
PubMed Link to Article
Raad  ICosterton  WSabharwal  USacilowski  MAnaissie  EBodey  G Ultrastructural analysis of indwelling vascular catheters: a quantitative relationship between luminal colonization and duration of placement. J Infect Dis. 1993;168400- 407
PubMed Link to Article
Maki  DWeise  CSarafin  H A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med. 1977;2961305- 1309
PubMed Link to Article
Pittet  DTarara  DWenzel  R Nosocomial bloodstream infection in critically ill patients: excess length of stay, extra costs, and attributable mortality. JAMA. 1994;2711598- 1601
PubMed Link to Article
Weinstein  R Device-related infections. Clin Infect Dis. 2001;331386
PubMed Link to Article
Crinch  CMaki  D The promise of novel technology for the prevention of intravascular device-related bloodstream infection, II: long-term devices. Clin Infect Dis. 2002;341362- 1368
PubMed Link to Article
Henderson  D Infections due to percutaneous intravascular devices. Mandell  GBennett  JDolin  RPrinciples and Practice of Infectious Diseases. Vol 2. Philadelphia, Pa Churchill Livingstone2000;3005- 3020
Yeung  CMay  JHughes  R Infection rate for single lumen v triple lumen subclavian catheters. Infect Control Hosp Epidemiol. 1988;9154- 158
PubMed Link to Article
Early  TGregory  RWheeler  JSnyder  SGayle  R Increased infection rate in double-lumen versus single-lumen Hickman catheters in cancer patients. South Med J. 1990;8334- 36
PubMed Link to Article
Merrer  JDe Jonghe  BGolliot  F  et al.  Complications of femoral and subclavian venous catheterization in critically ill patients. JAMA. 2001;286700- 707
PubMed Link to Article
Randolph  ACook  DGonzales  CBrun-Buisson  C Tunneling short-term central venous catheters to prevent catheter-related infection: a meta-analysis of randomized, controlled trials. Crit Care Med. 1998;261452- 1457
PubMed Link to Article
Maki  DGoldmnan  DRhame  F Infection control in intravenous therapy. Ann Intern Med. 1973;79867- 887
PubMed Link to Article
Raad  IHohn  DGilbreath  B  et al.  Prevention of central venous catheter-related infections by using maximal sterile barrier precautions during insertion. Infect Control Hosp Epidemiol. 1994;15231- 238
PubMed Link to Article
Maki  D Yes, Virginia, aseptic technique is very important: maximal sterile barrier precautions during insertion reduce the risk of central venous catheter-related bacteremia. Infect Control Hosp Epidemiol. 1994;15227- 230
PubMed Link to Article
Sherertz  REly  EWestbrook  D  et al.  Education of physicians-in-training can decrease the risk for vascular catheter infection. Ann Intern Med. 2000;132641- 648
PubMed Link to Article
Maki  DRinger  MAlvarado  C Prospective randomized trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet. 1991;338339- 343
PubMed Link to Article
Soifer  NBorzak  SEdlin  BWeinstein  R Prevention of peripheral venous catheter complications with an intravenous therapy team. Arch Intern Med. 1998;158473- 477
PubMed Link to Article
Veenstra  DSaint  SSaha  SLumley  TSullivan  S Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection. JAMA. 1999;281261- 267
PubMed Link to Article
Veenstra  DSaint  SSullivan  S Cost-effectiveness of antiseptic-impregnated central venous catheters for the prevention of catheter-related bloodstream infection. JAMA. 1999;282554- 560
PubMed Link to Article
Oda  THamasaki  JKanda  NMikami  K Anaphylactic shock induced by an antiseptic-coated central nervous (sic venous) catheter. Anesthesiology. 1997;871242- 1244
PubMed Link to Article
Centers for Devices and Radiological Health, US Food and Drug Administration, FDA public health notice: potential hypersensitivity reactions to chlorhexidine-impregnated medical devices. 1998;http://www.fda.gov/cdrh/chlorhex.html. Accessed November 27, 2002
Darouiche  RRaad  IHeard  S  et al.  A comparison of two antimicrobial-impregnated central venous catheters. N Engl J Med. 1999;3401- 8
PubMed Link to Article
Bassetti  SD'Agostino  RSherertz  R Prolonged antimicrobial activity of a catheter containing chlorhexidine-silver sulfadiazine extends protection against catheter infections in vivo. Antimicrob Agents Chemother. 2001;451535- 1538
PubMed Link to Article
Raad  IDarouiche  RDupuis  J  et al.  Central venous catheters coated with minocycline and rifampin for the prevention of catheter-related colonization and bloodstream infections. Ann Intern Med. 1997;127267- 274
PubMed Link to Article
Marik  PAbraham  GCareau  PVaron  JFromm  R The ex vivo antimicrobial activity and colonization rate of two antimicrobial-bonded central venous catheters. Crit Care Med. 1999;271128- 1131
PubMed Link to Article
Raad  IDarouiche  RHachem  R  et al.  Antimicrobial durability and rare ultrastructural colonization of indwelling central catheters coated with minocycline and rifampin. Crit Care Med. 1998;26219- 224
PubMed Link to Article
Raad  IBuzaid  ARhyne  J  et al.  Minocycline and ethylenediaminetetraacetate for the prevention of recurrent vascular catheter infections. Clin Infect Dis. 1997;25149- 151
PubMed Link to Article
Segura  MAlvarez-Lerma  FMa Tellado  J  et al.  A clinical trial on the prevention of catheter-related sepsis using a new hub model. Ann Surg. 1996;223363- 369
PubMed Link to Article
Raad  IHachem  RZermeno  ADumo  MBodey  G In vitro antimicrobial efficacy of silver iontophoretic catheter. Biomaterials. 1996;171055- 1059
PubMed Link to Article
Steele  LSolomon  SKritchevsky  S  et al.  Correlation between HICPAC recommendations for the prevention of intravascular device-related infections and reported practices in 53 hospitals participating in the evaluation of processes and indicators in infections control study [abstract]. Am J Infect Control. 2000;2889
Link to Article
Orskov  IFerencz  AOrskov  F Tamm-Horsfall protein or uromucoid is the normal urinary slime that traps type 1 fimbriated Escherichia coli.Lancet. 1980;1887
PubMed Link to Article
Buchanan  KFalkow  SHull  RHull  S Frequency among Enterobacteriaceae of the DNA sequences encoding type 1 pili. J Bacteriol. 1985;162799
PubMed
Reinhart  HObedeanu  NSobel  J Quantitation of Tamm-Horsfall protein binding to uropathogenic Escherichia coli and lectins. J Infect Dis. 1990;1621335- 1340
PubMed Link to Article
Garibaldi  RBurke  JBritt  MMiller  WSmith  C Meatal colonization and catheter-associated bacteriuria. N Engl J Med. 1980;303316- 318
PubMed Link to Article
Daifuku  RStamm  W Association of rectal and urethral colonization with urinary tract infection in patients with indwelling catheters. JAMA. 1984;2522028- 2030
PubMed Link to Article
Tambyah  PHalvorson  KMaki  D A prospective study of pathogenesis of catheter-associated urinary tract infections. Mayo Clin Proc. 1999;74131- 136
PubMed Link to Article
Stark  RMaki  D Bacteriuria in the catheterized patient. N Engl J Med. 1984;311560- 564
PubMed Link to Article
Saint  SLipsky  B Preventing catheter-related bacteruria: should we? can we? how? Arch Intern Med. 1999;159800- 808
PubMed Link to Article
Norden  CGreen  GKass  E Antibacterial mechanisms of the urinary bladder. J Clin Invest. 1968;472689- 2700
PubMed Link to Article
Merritt  JL Residual urine volume: correlate of urinary tract infection in patients with spinal cord injury. Arch Phys Med Rehabil. 1981;62558- 561
PubMed
Anderson  RU Non-sterile intermittent catheterization with antibiotic prophylaxis in the acute spinal cord injured male patient. J Urol. 1980;124392- 394
PubMed
Anderson  RU Prophylaxis of bacteriuria during intermittent catheterization of the acute neurogenic bladder. J Urol. 1980;123364- 366
PubMed
Lapides  JDiokno  ALowe  BKalish  M Followup on unsterile, intermittent self-catheterization. J Urol. 1974;111184- 187
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Warren  JTenney  JHoopes  JMuncle  HAnthony  W A prospective microbiologic study of bacteriuria in patients with chronic indwelling urethral catheters. J Infect Dis. 1982;146719- 723
PubMed Link to Article
Vainrub  BMusher  DM Lack of effect of methenamine in suppression of, or prophylaxis against, chronic urinary infection. Antimicrob Agents Chemother. 1977;12625- 629
PubMed Link to Article
Vickrey  BGShekelle  PMorton  SClark  KPathak  MKamberg  C Prevention and Management of Urinary Tract Infections in Paralyzed Persons.  Evidence Report/Technology Assessment No. 6. Rockville, Md Agency for Health Care Policy and Research: Southern California Evidence-Based Practice Center/RAND under contract No. 290-97-00011999;
Hetey  SKKleinberg  MLParker  WDJohnson  EW Effect of ascorbic acid on urine pH in patients with injured spinal cords. Am J Hosp Pharm. 1980;37235- 237
PubMed
Castello  TGirona  LGomez  MRMena Mur  AGarcia  L The possible value of ascorbic acid as a prophylactic agent for urinary tract infection. Spinal Cord. 1996;34592- 593
PubMed Link to Article
Stover  SLFleming  WC Recurrent bacteriuria in complete spinal cord injury patients on external condom drainage. Arch Phys Med Rehabil. 1980;61178- 181
PubMed
Pearman  JW The value of kanamycin-colistin bladder instillations in reducing bacteriuria during intermittent catheterisation of patients with acute spinal cord injury. Br J Urol. 1979;51367- 374
PubMed Link to Article
Pearman  JWBailey  MHarper  WES Comparison of the efficacy of "Trisdine" and kanamycin-colistin bladder instillations in reducing bacteriuria during intermittent catheterisation of patients with acute spinal cord trauma. Br J Urol. 1988;62140- 144
PubMed Link to Article
Maizels  MSchaeffer  AJ Decreased incidence of bacteriuria associated with periodic instillations of hydrogen peroxide into the urethral catheter drainage bag. J Urol. 1980;123841- 845
PubMed
Gilmore  DSAeilts  GDAlldis  BA  et al.  Effects of bathing on Pseudomonas and Klebsiella colonization in patients with spinal cord injuries. J Clin Microbiol. 1981;14404- 407
PubMed
Gilmore  DSMontgomerie  JZGraham  IEShick  DGJimenez  EM Effect of antiseptic agents on skin flora of the perineum of men with spinal cord injury. Infect Control. 1984;5431- 434
PubMed
Montgomerie  JZGilmore  DSGraham  IESchick  DG The effects of antiperspirant on the perineal skin flora of patients with spinal cord injury. J Hosp Infect. 1988;1243- 49
PubMed Link to Article
Sanderson  PJWeissler  S A comparison of the effect of chlorhexidine antisepsis, soap and antibiotics on bacteriuria, perineal colonization and environmental contamination in spinally injured patients. J Hosp Infect. 1990;15235- 243
PubMed Link to Article
Stickler  D Susceptibility of antibiotic-resistant Gram-negative bacteria to biocides: a perspective from the study of catheter biofilms. J Appl Microbiol. 2002;92163S- 170S
PubMed Link to Article
Warren  J Catheter-associated urinary tract infections. Infect Dis Clin North Am. 1997;11609- 622
PubMed Link to Article
Kunin  CMcCormick  R Prevention of catheter-associated urinary-tract infections by sterile closed drainage. N Engl J Med. 1966;2741154- 1161
Kass  E Asymptomatic infections of the urinary tract. Trans Am A Physicians. 1956;6956- 64
Erickson  RPMerritt  JLOpitz  JLIlstrup  MS Bacteriuria during follow-up in patients with spinal cord injury, I: rates of bacteriuria in various bladder-emptying methods. Arch Phys Med Rehabil. 1982;63409- 412
PubMed
Siroky  M Pathogenesis of bacteriuria and infection in the spinal cord injured patient. Am J Med. 2002;11367S- 79S
PubMed Link to Article
Saint  SLipsky  BGoold  S Indwelling urinary catheters: a one-point restraint? Ann Intern Med. 2002;137125- 128
PubMed Link to Article
Saint  SElmore  JGSullivan  SDEmerson  SSKoepsell  TD The efficacy of silver alloy-coated urinary catheters in preventing urinary tract infection: a meta-analysis. Am J Med. 1998;105236- 241
PubMed Link to Article
Schaeffer  AJStory  KOJohnson  SM Effect of silver oxide/trichloroisocyanuric acid antimicrobial urinary drainage system on catheter-associated bacteriuria. J Urol. 1988;13969- 73
PubMed
Darouiche  RSmith  JHanna  H  et al.  Efficacy of antimicrobial-impregnated bladder catheters in reducing catheter-associated bacteriuria: a prospective, randomized, multicenter clinical trial. Urology. 1999;54976- 981
PubMed Link to Article
Guay  D An update on the role of nitrofurans in the management of urinary tract infections. Drugs. 2001;61353- 364
PubMed Link to Article
Johnson  JDelavari  PAzar  M Activities of a nitrofurazone-containing urinary catheter and a silver hydrogel catheter against multidrug-resistant bacteria characteristic of catheter-associated urinary tract infection. Antimicrob Agents Chemother. 1999;432990- 2995
PubMed
Patterson  TAndriole  V Detection, significance, and therapy of bacteriuria in pregnancy. Infect Dis Clin North Am. 1997;11593- 609
PubMed Link to Article
Zhanel  GHarding  GGuay  D Asymptomatic bacteriuria: which patients should be treated? Arch Intern Med. 1990;1501389- 1396
PubMed Link to Article
Harding  GZhanel  GNicolle  LCheang  M Antimicrobial treatment in diabetic women with asymptomatic bacteriuria. N Engl J Med. 2002;3471576- 1583
PubMed Link to Article
Hansson  SJodal  ULincoln  K Untreated asymptomatic bacteriuria in girls: II—effect of phenoxymethylpenicillin and erythromycin given for intercurrent infections. BMJ. 1989;298856
PubMed Link to Article
Tencer  J Asymptomatic bacteriuria—a long-term study. Scand J Urol Nephrol. 1988;2231- 34
PubMed
Reid  GBruce  ATaylor  M Influence of three-day antimicrobial therapy and lactobacillus vaginal suppositories on recurrence of urinary tract infections. Clin Ther. 1992;1411- 16
PubMed
Reid  GBruce  AMcGroarty  JCheng  KCosterton  J Is there a role for lactobacilli in prevention of urogenital and intestinal infections? Clin Microbiol Rev. 1990;3335
PubMed
Bruce  AReid  G Intravaginal instillation of lactobacilli for prevention of recurrent urinary tract infections. Can J Microbiol. 1988;34339- 343
PubMed Link to Article
Hull  RRudy  DDonovan  W  et al.  Urinary tract infection prophylaxis using Escherichia coli 83972 in spinal cord injured patients. J Urol. 2000;163872- 877
PubMed Link to Article
Darouiche  RDonovan  WDel Terzo  MThornby  JRudy  DHull  R Pilot trial of bacterial interference for preventing urinary tract infection. Urology. 2001;58339- 344
PubMed Link to Article
Trautner  BDarouiche  RHull  RHull  SThornby  J Pre-inoculation of urinary catheters with Escherichia coli 83972 inhibits catheter colonization by Enterococcus faecalis.J Urol. 2002;167375- 379
PubMed Link to Article

Figures

Tables

Table Graphic Jump LocationTable 1. Categories of Preventive Strategies
Table Graphic Jump LocationTable 2. Differences in Pathogenesis of Infection of Vascular and Urinary Catheters

References

Richards  MEdwards  JCulver  DGaynes  R Nosocomial infections in medical intensive care units in the United States. National Nosocomial Infections Surveillance System. Crit Care Med. 1999;27887- 892
PubMed Link to Article
Darouiche  R Device-associated infections: a macroproblem that starts with microadherence. Clin Infect Dis. 2001;331567- 1572
PubMed Link to Article
Not Available, Guidelines for the prevention of intravascular catheter-related infections. MMWR Morb Mortal Wkly Rep. 2002;511- 29
Maki  DTambyah  P Engineering out the risk of infection with urinary catheters. Emerg Infect Dis. 2001;71- 13
PubMed Link to Article
Saint  S Clinical and economic consequences of nosocomial catheter-related bacteriuria. Am J Infect Control. 2000;2868- 75
PubMed Link to Article
Habash  MReid  G Microbial biofilms: their development and significance for medical-device related infections. J Clin Pharmacol. 1999;39887
PubMed Link to Article
Destedt  JWollin  TReid  G Biomaterials used in urology: current issues of biocompatibility, infection, and encrustation. J Endourol. 1998;12493- 500
PubMed Link to Article
Watnick  PKolter  R Biofilm, city of microbes. J Bacteriol. 2000;1822675- 2679
PubMed Link to Article
Appelgren  PRansjo  UBindslev  LEspersen  FLarm  O Surface heparinization of central venous catheters reduces microbial colonization in vitro and in vivo: results from a prospective, randomized trial. Crit Care Med. 1996;241482- 1489
PubMed Link to Article
Schembri  MKlemm  P Biofilm formation in a hydrodynamic environment by novel FimH variants and ramifications for virulence. Infect Immun. 2001;691322- 1328
PubMed Link to Article
Donlan  R Biofilm formation: a clinically relevant microbiological process. Clin Infect Dis. 2001;331387- 1392
PubMed Link to Article
Thomas  WTrintchina  EForero  MVogel  VSokurenko  E Bacterial adhesion to target cells enhanced by shear force. Cell. 2002;109913- 923
PubMed Link to Article
Davies  DParsek  MPearson  JIglewski  BCosterton  JGreenberg  E The involvement of cell-to-cell signals in the development of a bacterial biofilm. Science. 1998;280295- 298
PubMed Link to Article
Costerton  JStewart  PGreenberg  E Bacterial biofilms: a common cause of persistent infections. Science. 1999;2841318- 1322
PubMed Link to Article
Nickel  JCosteron  JMcLean  ROlson  M Bacterial biofilms: influence on the pathogenesis, diagnosis and treatment of urinary tract infections. J Antimicrob Chemother. 1994;3331- 41
PubMed Link to Article
Raad  IBodey  G Infectious complications of indwelling vascular catheters. Clin Infect Dis. 1992;15197- 210
PubMed Link to Article
Crinch  CMaki  D The promise of novel technology for the prevention of intravascular device-related bloodstream infection, I: pathogenesis and short-term devices. Clin Infect Dis. 2002;341232- 1242
PubMed Link to Article
Raad  IHanna  H Intravascular catheter-related infections. Arch Intern Med. 2002;162871- 878
PubMed Link to Article
Anaissie  ESamonis  GKontoyiannis  D  et al.  Role of catheter colonization and infrequent hematogenous seeding in catheter-related infections. Eur J Clin Microbiol Infect Dis. 1995;14134- 137
PubMed Link to Article
Passerini  LLan  KCosterton  JKing  E Biofilms on indwelling vascular catheters. Crit Care Med. 1992;20665- 673
PubMed Link to Article
Raad  ICosterton  WSabharwal  USacilowski  MAnaissie  EBodey  G Ultrastructural analysis of indwelling vascular catheters: a quantitative relationship between luminal colonization and duration of placement. J Infect Dis. 1993;168400- 407
PubMed Link to Article
Maki  DWeise  CSarafin  H A semiquantitative culture method for identifying intravenous-catheter-related infection. N Engl J Med. 1977;2961305- 1309
PubMed Link to Article
Pittet  DTarara  DWenzel  R Nosocomial bloodstream infection in critically ill patients: excess length of stay, extra costs, and attributable mortality. JAMA. 1994;2711598- 1601
PubMed Link to Article
Weinstein  R Device-related infections. Clin Infect Dis. 2001;331386
PubMed Link to Article
Crinch  CMaki  D The promise of novel technology for the prevention of intravascular device-related bloodstream infection, II: long-term devices. Clin Infect Dis. 2002;341362- 1368
PubMed Link to Article
Henderson  D Infections due to percutaneous intravascular devices. Mandell  GBennett  JDolin  RPrinciples and Practice of Infectious Diseases. Vol 2. Philadelphia, Pa Churchill Livingstone2000;3005- 3020
Yeung  CMay  JHughes  R Infection rate for single lumen v triple lumen subclavian catheters. Infect Control Hosp Epidemiol. 1988;9154- 158
PubMed Link to Article
Early  TGregory  RWheeler  JSnyder  SGayle  R Increased infection rate in double-lumen versus single-lumen Hickman catheters in cancer patients. South Med J. 1990;8334- 36
PubMed Link to Article
Merrer  JDe Jonghe  BGolliot  F  et al.  Complications of femoral and subclavian venous catheterization in critically ill patients. JAMA. 2001;286700- 707
PubMed Link to Article
Randolph  ACook  DGonzales  CBrun-Buisson  C Tunneling short-term central venous catheters to prevent catheter-related infection: a meta-analysis of randomized, controlled trials. Crit Care Med. 1998;261452- 1457
PubMed Link to Article
Maki  DGoldmnan  DRhame  F Infection control in intravenous therapy. Ann Intern Med. 1973;79867- 887
PubMed Link to Article
Raad  IHohn  DGilbreath  B  et al.  Prevention of central venous catheter-related infections by using maximal sterile barrier precautions during insertion. Infect Control Hosp Epidemiol. 1994;15231- 238
PubMed Link to Article
Maki  D Yes, Virginia, aseptic technique is very important: maximal sterile barrier precautions during insertion reduce the risk of central venous catheter-related bacteremia. Infect Control Hosp Epidemiol. 1994;15227- 230
PubMed Link to Article
Sherertz  REly  EWestbrook  D  et al.  Education of physicians-in-training can decrease the risk for vascular catheter infection. Ann Intern Med. 2000;132641- 648
PubMed Link to Article
Maki  DRinger  MAlvarado  C Prospective randomized trial of povidone-iodine, alcohol, and chlorhexidine for prevention of infection associated with central venous and arterial catheters. Lancet. 1991;338339- 343
PubMed Link to Article
Soifer  NBorzak  SEdlin  BWeinstein  R Prevention of peripheral venous catheter complications with an intravenous therapy team. Arch Intern Med. 1998;158473- 477
PubMed Link to Article
Veenstra  DSaint  SSaha  SLumley  TSullivan  S Efficacy of antiseptic-impregnated central venous catheters in preventing catheter-related bloodstream infection. JAMA. 1999;281261- 267
PubMed Link to Article
Veenstra  DSaint  SSullivan  S Cost-effectiveness of antiseptic-impregnated central venous catheters for the prevention of catheter-related bloodstream infection. JAMA. 1999;282554- 560
PubMed Link to Article
Oda  THamasaki  JKanda  NMikami  K Anaphylactic shock induced by an antiseptic-coated central nervous (sic venous) catheter. Anesthesiology. 1997;871242- 1244
PubMed Link to Article
Centers for Devices and Radiological Health, US Food and Drug Administration, FDA public health notice: potential hypersensitivity reactions to chlorhexidine-impregnated medical devices. 1998;http://www.fda.gov/cdrh/chlorhex.html. Accessed November 27, 2002
Darouiche  RRaad  IHeard  S  et al.  A comparison of two antimicrobial-impregnated central venous catheters. N Engl J Med. 1999;3401- 8
PubMed Link to Article
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