0
Editor's Correspondence |

Risk of Unexplained Acute Liver Failure in Diabetes Mellitus—Reply

K. Arnold Chan, MD ScD; Alison Truman, MS; Jerry H. Gurwitz, MD; Judith Hurley, RD MS; Brian Martinson, PhD; Richard Platt, MD MS; Richard Moseley, MD; Joe Selby, MD MPH
Arch Intern Med. 2003;163(21):2650-2651. doi:10.1001/archinte.163.21.2649-a.
Text Size: A A A
Published online

Extract

In reply

Dr Graham claims that our study overestimated the rate of ALF and implies that the sponsor had undue influence over the study design. The essence of ALF is diminished hepatic function occurring over a period of a few months.1 Our criteria for probable ALF were new-onset encephalopathy, hyperbilirubinemia, and coagulopathy. At least one of these criteria of impaired liver function was required for a diagnosis of possible ALF. In our study,2 10 of 26 patients with probable or possible ALF without probable cause other than use of hypoglycemic agents had encephalopathy. If we count only these 10 patients, as Graham suggests, the ALF incidence estimate among patients using hypoglycemic agents would be approximately 4 per 100 000, still higher than the 1 per million rate he cites, and would not substantially alter our conclusion.

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles
Jobs
JAMAevidence.com
brightcove.createExperiences();