There have been abundant studies of the effects of exercise, weight loss, dietary lipids (especially omega-3 polyunsaturated fatty acids), smoking, alcohol, and psychosocial stress on the 3 main systems of thrombogenesis. The data from intervention and randomized clinical trials are largely fragmented, rarely complete, and inconsistent, mainly due to the differences in study design. However, the evidence from these studies suggests that lifestyle changes that adopt strategies to lose weight, stop cigarette smoking, engage in regular moderate exercise and relaxation, and regularly consume light to moderate alcohol and fatty fish would improve the hemostatic profile. The overall effects may translate into improved clinical outcomes in healthy individuals, those with cardiovascular risk factors, or those with established vascular disease. It follows that cardiac rehabilitation programs that incorporate a stepwise increment of physical training or exercise, patient education and advice, dietary and personal habit modifications, and psychosocial stress management would have a significant impact on patients' hemostatic profiles and beneficially influence the overall cardiovascular risk.