Dr Dalen's1 reply to the comments of Mukherjee and colleagues2 suggests the possibility of a clinical trial to attempt to answer the question if naproxen decreases the risk of myocardial infarction or if cyclooxygenase inhibitors increase the risk. One of the proposed treatment arms would include patients receiving both naproxen and aspirin. To be credible, such a project would require a preliminary evaluation to see if there is any modulation of the cardioprotective effect of naproxen when it is used in conjunction with aspirin. A previously published study with ibuprofen (another propionic acid derivative) showed a blockage of aspirin's effect on inhibition of thromboxane B2 formation as well as platelet aggregation.3
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Country-Specific Mortality and Growth Failure in Infancy and Yound Children and
Association With Material Stature
Use interactive graphics and maps to view and sort country-specific infant and early
dhildhood mortality and growth failure data and their association with maternal
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