THIS CALL-TO-ACTION document is an initiative of the Prevention of Atherothrombotic Disease Network, an international, multidisciplinary network, adjoined by the mutual goal of increasing awareness, detection, and treatment rates of peripheral arterial disease (PAD) and increasing awareness of the interrelationship between PAD and the risk of ischemic events. Although the prevalence of PAD in Europe and North America is estimated at approximately 27 million people, PAD remains a largely underdiagnosed and undertreated disease. Several recent epidemiologic studies have revealed PAD detection rates of 20% to 30% when specific at-risk populations were screened. In an effort to guide diagnostic and treatment protocols, the Prevention of Atherothrombotic Disease Network has recommended 5 action items. These are to (1) increase awareness of PAD and its consequences; (2) improve the identification of patients with symptomatic PAD; (3) initiate a screening protocol for patients at high risk for PAD; (4) improve treatment rates among patients who have been diagnosed with symptomatic PAD; and (5) increase the rates of early detection among the asymptomatic population.
The 10-year survival rate for patients with and without peripheral arterial disease, as evidenced by the San Diego Artery Study.23
The survival rate over 15 years for patients with symptomatic peripheral arterial disease (PAD) vs control patients. Depicted is the relationship between the presence of symptomatic PAD and survival rate.24,25
The 5-year mortality rates for common pathological conditions. The outcome from time of diagnosis of peripheral arterial disease (PAD) was found to be worse than the outcome for breast cancer and Hodgkin disease.27,28
Common peripheral arterial disease (PAD) risk factors. Depicted is the range of odds ratios for developing symptomatic PAD. Excluding unmodifiable factors, the most important risk factors for developing intermittent claudication are diabetes and smoking.24,25
Thank you for submitting a comment on this article. It will be reviewed by JAMA Internal Medicine editors. You will be notified when your comment has been published. Comments should not exceed 500 words of text and 10 references.
Do not submit personal medical questions or information that could identify a specific patient, questions about a particular case, or general inquiries to an author. Only content that has not been published, posted, or submitted elsewhere should be submitted. By submitting this Comment, you and any coauthors transfer copyright to the journal if your Comment is posted.
* = Required Field
Disclosure of Any Conflicts of Interest*
Indicate all relevant conflicts of interest of each author below, including all relevant financial interests, activities, and relationships within the past 3 years including, but not limited to, employment, affiliation, grants or funding, consultancies, honoraria or payment, speakers’ bureaus, stock ownership or options, expert testimony, royalties, donation of medical equipment, or patents planned, pending, or issued. If all authors have none, check "No potential conflicts or relevant financial interests" in the box below. Please also indicate any funding received in support of this work. The information will be posted with your response.
Some tools below are only available to our subscribers or users with an online account.
Download citation file:
Web of Science® Times Cited: 282
Customize your page view by dragging & repositioning the boxes below.
More Listings atJAMACareerCenter.com >
Users' Guides to the Medical Literature
Peripheral Arterial Disease or Peripheral Vascular Insufficiency
The Rational Clinical Examination
Make the Diagnosis: Peripheral Arterial Disease
All results at
Enter your username and email address. We'll send you a link to reset your password.
Enter your username and email address. We'll send instructions on how to reset your password to the email address we have on record.
Athens and Shibboleth are access management services that provide single sign-on to protected resources. They replace the multiple user names and passwords necessary to access subscription-based content with a single user name and password that can be entered once per session. It operates independently of a user's location or IP address. If your institution uses Athens or Shibboleth authentication, please contact your site administrator to receive your user name and password.