Stroke is the third leading cause of mortality after coronary heart disease and cancer and the leading cause of disability. Although lowering blood cholesterol level decreases the risk of coronary heart disease, whether it decreases the risk of stroke remains unclear. Previous overviews suggested that hydroxymethylglutaryl coenzyme A reductase inhibitors (statins), but not other lipid-lowering therapy (LLT), may reduce stroke incidence in coronary patients. To investigate the amplitude and sources of heterogeneity of LLT effects on stroke prevention, Corvol et al searched the literature from 1966 to 2001 and then conducted a meta-analysis including randomized trials of primary and secondary coronary heart disease prevention, testing statins, nonstatin drugs, diet, or other interventions and providing data on stroke incidence. The meta-analysis (38 trials, 83 161 patients, mean follow-up of 4.7 years) showed a significant relative risk reduction of strokes by LLT of 17% (P<.001), without significant heterogeneity between trials and between subgroups according to either the type of prevention #1primary or secondary) or the type of LLT. The most substantial effects were obtained, however, with statins (relative risk reduction, 26%). Corvol et al conclude that LLT appears to reduce stroke incidence in coronary patients and that such benefit appears to be related to blood cholesterol lowering, explaining why statin drugs provide the most consistent benefit among trials.