Fung et al prospectively assessed the associations between major dietary patterns and the risks of colorectal cancer in women. Dietary information was collected in 1984, 1986, 1990, and 1994 from 76 402 women aged 38 to 63 years without history of cancer in 1984. The authors conducted factor analysis and identified 2 major dietary patterns: "prudent" and "Western." The prudent pattern was characterized by higher intakes of fruits, vegetables, legumes, fish, poultry, and whole grains, whereas the Western pattern was characterized by higher intakes of red and processed meats, sweets and desserts, french fries, and refined grains. The authors then calculated pattern scores for each participant and examined prospectively the associations between dietary pattern scores and colon and rectal cancer risks. During 12 years of follow-up, 445 cases of colon cancer and 101 cases of rectal cancer were identified. After adjusting for potential confounders, a relative risk for colon cancer of 1.46 (95% confidence interval, 0.97-2.19) was observed when comparing the highest to lowest quintiles of the Western pattern (P value for trend across quintiles, .02). The prudent pattern had a nonsignificant inverse association with colon cancer. The authors did not observe any significant association between dietary patterns and rectal cancer.