Despite declines in blood lead levels over the past 20 years, lead exposure continues to be a public health concern. Studies have linked lead exposure with increased risk of diverse health outcomes. To evaluate the association of lead exposure and mortality in the United States, Lustberg and Silbergeld used the recently released mortality follow-up data for participants of the Second National Health and Nutrition Examination Survey, conducted from 1976 to 1980. After adjustment for potential confounders, individuals with blood lead levels of 20 to 29 µg/dL (15% of the adult population at the time) had 46% increased all-cause mortality (rate ratio [RR], 1.46; 95% confidence interval [CI], 1.14-1.86), 39% increased circulatory mortality (RR, 1.39; 95% CI, 1.01-1.91), and 68% increased cancer mortality (RR, 1.68; 95% CI, 1.02-2.78) compared with those with blood lead levels less than 10 µg/dL. In light of this finding, the authors strongly encourage efforts at lead abatement for the 1.7 million people in the United States with blood lead levels of 20 µg/dL or greater.