Editor's Correspondence |

The Arterial Inflammation Hypothesis

Deepak L. Bhatt, MD; Eric J. Topol, MD
Arch Intern Med. 2002;162(19):2249-2251. doi:.
Text Size: A A A
Published online


We read with interest the recent commentary by Kushner and Sehgal1 regarding the use of high-sensitivity C-reactive protein (hs-CRP) as a screening test for cardiovascular risk. Interestingly, many of the arguments lodged against the use of hs-CRP are the same as the ones initially used against measurement of cholesterol levels. Numerous studies in diverse populations have shown the value of hs-CRP in predicting risk, independent of other established markers.2 Even an incremental ability to prognosticate risk above and beyond stress testing and coronary angiography has been demonstrated.35 High-sensitivity CRP has now been proven to predict the risk of sudden cardiac death, a major cause of mortality that lacks effective preventive therapies.6 Furthermore, it appears that CRP is not just an innocent bystander in atherosclerosis, but actually has a direct pathogenic role in arterial disease.7 Studies have documented the ability of CRP to activate complement, to increase the uptake of low-density lipoprotein by macrophages, and to enhance T-cell–mediated endothelial cell destruction.810 In fact, patients with elevated levels of hs-CRP have more CRP in their plaque.6



Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Topics
PubMed Articles