Little data exist on end-of-life care practices in Asian intensive care units (ICUs). Phua and colleagues conducted a questionnaire survey on 1465 physicians who cared for patients in 466 ICUs in 16 Asian countries and regions. For patients with no real chance of recovering a meaningful life, 70.2% of respondents reported almost always or often withholding life-sustaining treatments, whereas 20.7% reported almost always or often withdrawing life-sustaining treatments; 74.5% deemed withholding and withdrawal ethically different. Attitudes and practice varied widely across countries and regions. Multiple factors related to country and region, including economic, cultural, religious, and legal differences, as well as personal attitudes, were associated with these variations. Koh and Hwee provide an Invited Commentary.