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Clinical Observation |

Brugada Syndrome:  An Unusual Cause of Convulsive Syncope

Hakan Paydak, MD; E. Andrew Telfer, MD; Richard F. Kehoe, MD; Priya Balasubramanian, MD; Leela Narra, MD; Marilyn Ezri, MD; Terry Zheutlin, MD; Pradeep Maheshwari, MD; Jose Nazari, MD; Theodore Wang, MD
Arch Intern Med. 2002;162(12):1416-1419. doi:10.1001/archinte.162.12.1416.
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A patient who presented with a new apparent seizure was found to have abnormal electrocardiographic findings, with classic features of the Brugada syndrome. He had spontaneous episodes of nonsustained ventricular tachycardia, easily inducible ventricular fibrillation at electrophysiological study in the absence of structural heart disease, and a negative neurological evaluation. These findings suggested that sustained ventricular arrhythmias known to be associated with the Brugada syndrome and resultant cerebral hypoperfusion, rather than a primary seizure disorder, were responsible for the event. Patients with the Brugada syndrome often present with sudden death or with syncope resulting from ventricular arrhythmias. In consideration of its variability in presentation sometimes mimicking other disorders, primary care physicians and internists should be aware of its often transient electrocardiographic features.

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Standard electrocardiograms illustrating the classic features of the Brugada syndrome in leads V1 through V3 (A), with subsequent normalization of the right bundle branch pattern and ST segment elevation (B).

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