Diagnosing dermatological disorders may be difficult, and subtle differences in their clinical features require a specific diagnostic competence to avoid incorrect interpretations. We do not agree with the diagnosis in a case that was reported by Carrillo-Jimenez et al1 in the June 25, 2001, issue of the ARCHIVES.
The patient involved had a hyperacute rash with fever, asthenia, sore throat, chills, and polyarthralgia that had developed after 2½ weeks of bupropion treatment. The skin lesions had a figurate appearance and were fiery red. Laboratory tests revealed only leukocytosis (white blood cell count, 14.3 × 103/µL) with 91% neutrophils. Intravenous methylprednisolone therapy cleared the lesions in 24 hours. The diagnosis was erythema multiforme due to bupropion use.