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Clinical Observation |

Drug-Induced Lupus Erythematosus by Amiodarone

Abdalhamid Sheikhzadeh, MD, FACC, FESC, FASE; Ulrich Schäfer, MD; Armin Schnabel, MD
Arch Intern Med. 2002;162(7):834-836. doi:10.1001/archinte.162.7.834.
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We report a case with typical clinical features of drug-induced lupus erythematosus, together with verrucous endocarditis and pleuropericardial effusion, due to amiodarone treatment. After cessation of amiodarone treatment, the patient recovered completely.

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A, Laboratory findings of the levels of C-reactive protein (CRP), body temperature, and white blood cell count (WBCC) in our patient during the 5 weeks after admission. Daily dosages of antibiotics are given above the top graph. ANA indicates antinuclear antibodies. B, Transesophageal echocardiographic findings of the vegetation. LA indicates left atrium; LV, left ventricle; PML, posterior mitral leaflet; and AML, anterior mitral leaflet. C, Echocardiographic findings of the pericardial effusion (PE). RVW indicates right ventricular wall; IVS, interventricular septum; and LVPW, left ventricular posterior wall.

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