The PEPI-RCT was supported by cooperative agreement research grants U01-HL40154, U01-HL40185, UL-HL40195, U01-HL40205, U01-HL40207, U01-HL40231, U01-HL40232, and U01-HL40273 from the National Heart, Lung, and Blood Institute, the National Institute of Child Health and Human Development, the National Institute of Arthritis and Musculoskeletal and Skin Diseases, the National Institute of Diabetes, Digestive and Kidney Diseases, and the National Institute on Aging, Bethesda, Md. Packaged medication and placebos for the PEPI-RCT were provided by Wyeth-Ayerst Laboratories, St David's, Pa; Schering-Plough Research Institute, Kenilworth, NJ; and The Upjohn Company (now Pharmacia Corp), Peapack, NJ. The PSFS was funded in whole with federal funds from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Md, under contracts N01-HV-48132, N01-HV-48133, N01-HV-48139. Funds to obtain BMD measurements were provided by the National Institute of Arthritis and Musculoskeletal and Skin Diseases. Dr Greendale was also supported for this work by the Iris Cantor–University of California at Los Angeles Women's Center and by grant PHS 282-97-0025 from the University of California at Los Angeles Center of Excellence in Women's Health.