Interferon has been used as the standard therapy for chronic hepatitis C. However, interferon use has various adverse effects, including depression, hematological abnormalities, and autoimmune diseases. Autoimmune diseases are induced by either the exacerbation of preexisting disorders or de novo induction.1,2 These effects are attributed to the immunomodulatory effects of interferon. We describe a rare patient who developed capillary leak syndrome with monoclonal gammopathy after successful treatment with interferon alfa for her chronic hepatitis C.
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