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Original Investigation |

Acupuncture for Back Pain:  A Meta-Analysis of Randomized Controlled Trials FREE

Edzard Ernst, MD, PhD, FRCP(Edin); Adrian R. White, MD
[+] Author Affiliations

From the Department of Complementary Medicine, Postgraduate Medical School, University of Exeter, Exeter, England.


Arch Intern Med. 1998;158(20):2235-2241. doi:10.1001/archinte.158.20.2235.
Text Size: A A A
Published online

Background  Acupuncture is commonly used to treat back pain, but there is no published meta-analysis of trials of its effectiveness for this condition.

Objective  To perform a meta-analysis of trials of acupuncture for the treatment of back pain.

Methods  A systematic literature search was conducted to retrieve all randomized controlled trials of any form of acupuncture for any type of back pain in humans. The adequacy of the acupuncture treatment was assessed by consulting 6 experienced acupuncturists. The main outcome measure for the meta-analysis was numbers of patients whose symptoms were improved at the end of treatment.

Results  Twelve studies were included, of which 9 presented data suitable for meta-analysis. The odds ratio of improvement with acupuncture compared with control intervention was 2.30 (95% confidence interval, 1.28-4.13). For sham-controlled, evaluator-blinded studies, the odds ratio was 1.37 (95% confidence interval, 0.84-2.25).

Conclusion  Acupuncture was shown to be superior to various control interventions, although there is insufficient evidence to state whether it is superior to placebo.

Figures in this Article

BACK PAIN is among the most prevalent health complaints of mankind.1 It is, therefore, associated with much individual suffering and considerable socioeconomic consequences.2 Back pain is also the most frequent indication for using unconventional therapies.35 Survey data suggest that back pain is one of the most common indications for referral to acupuncturists.6

Against this background, it is relevant to ask whether acupuncture can be shown to be effective. Even though several plausible mechanisms exist to explain its analgesic actions,7 reviews of acupuncture as a treatment for painful conditions invariably conclude that the published data are insufficient to judge it as effective or ineffective.812 As different pain syndromes could respond differently to acupuncture, and as no systematic review or meta-analysis of acupuncture for back pain exists, the present study was aimed at filling this gap.

DATA SOURCES

Searches were performed for clinical trials of any form of acupuncture for back pain in 3 computerized databases: MEDLINE (1969-1996); the Cochrane Controlled Trials Register (Issue 1, 1997); and CISCOM (November 1996), a database specializing in complementary medicine including much of the "gray literature," such as unpublished studies and conference reports. Searches were performed using keywords acupuncture, electroacupuncture, and backache and text-word searches for the above terms together with low-back pain and lumbago. In addition, our files of published articles selected over the years were screened and several experts in different countries were invited to contribute published studies on the topic. The bibliographies of all articles thus retrieved together with reviews of acupuncture treatment of pain were reviewed for further references. Authors of articles published in the past 5 years (1992-1997) were contacted and asked to inform us of any other articles they were aware of. Authors of abstracts were contacted and asked to provide the full reports.

STUDY SELECTION

All articles that reported a randomized controlled trial in which dry needles were inserted into the skin and for which the process was described by the author(s) as "acupuncture" for the treatment of any type of back pain in humans were included. The basis for selecting points for needle insertion was not restricted. Articles published in the English, French, German, Spanish, Italian, or Polish language were included. Trials in which one form of acupuncture was compared with another were excluded. When more than 1 publication described a single trial, only 1 report was included.

DATA EXTRACTION

Data were extracted independently by both of us in a predefined, standardized manner. Differences were settled by discussion. For each trial, numbers of patients in experimental and control groups who were objectively rated as improved or who had returned to work were obtained. Where objective measures were not available, subjective ratings were used. Where more than 1 outcome measure was reported in this way, the least and most favorable results were extracted for separate evaluations. Where necessary, letters were sent to authors requesting these data.

ASSESSMENT OF METHODOLOGICAL QUALITY

The quality of the studies was assessed by a modification of the method described by Jadad et al.13 First, points were awarded by the investigators (E.E. and A.R.W.) in 3 categories: randomization (2 points), blinding (2 points), and description of dropouts and withdrawals (1 point). Studies were rated as "blind" if the control group received an intervention that appears likely to be indistinguishable from acupuncture (ie, sham acupuncture) and if the outcome was assessed in a blind manner, whether by a blinded observer or by the blinded subject's self-report. Second, points up to a maximum of 2 were awarded for each study according to the adequacy of the acupuncture treatment used, as assessed by blinded experts. For this purpose, an extract was prepared for each study containing only details of patients and interventions, translated into English if necessary. All means of identification were removed. Six experienced medical acupuncturists involved both in clinical practice and in teaching studied these extracts and rated the adequacy of acupuncture in each trial on a visual analog scale (VAS) that consisted of a 100-mm line. The left end of the line was labeled "complete absence of evidence that the acupuncture was adequate" and the right end was labeled "total certainty that the acupuncture was adequate." Two points were awarded for mean VAS scores of more than 66, one point for scores between 33 and 66, and zero points for scores less than 33 mm.

DATA SYNTHESIS

Meta-analyses of the data were performed using custom-written software (RevMan 3.0, Cochrane Collaboration, Oxford, England). For each trial, the total numbers of patients included in each group and the numbers whose symptoms had improved were entered into tables for comparison. Subsequently, the odds ratio (OR) for each trial was calculated, ie, the ratio of successes to failures in the genuine treatment group, divided by the same ratio in the control group. Weighting studies according to their inverse variance, the program computed a combined OR for all trials in the comparison, using the random effects model of DerSimonian and Laird.14 Confidence intervals (CIs) were calculated from the sums of the individual variances, and were set at 95%. The primary meta-analysis combined all studies that contained data in the appropriate form. Further meta-analyses were performed to compare subsets of trials that were combined according to particular features: blinding, length of follow-up, adequacy of acupuncture, use of formula acupuncture or electrical stimulation, and number of treatment sessions.

SENSITIVITY ANALYSIS

The primary meta-analysis was performed using the data that were least favorable to acupuncture. A sensitivity analysis was performed by repeating this meta-analysis using the most favorable data.

STUDIES IDENTIFIED

The search revealed 30 references for controlled trials.1544 Eighteen reports were excluded for the reasons given in Table 1.

Table Graphic Jump LocationTable 1. Meta-analysis of Acupuncture for Back Pain: Trials Excluded and the Reasons for Exclusion

Table 2 summarizes the key data from the 12 studies that were included. In 2 studies, patients were recruited after admission to hospital, either for a course of rehabilitation30 or for management of acute back pain.17 Patients were recruited via media advertisements in 1 study.16 In the remaining 9 trials, patients were recruited from hospital outpatient departments. In 4 studies,16,18,22,32 patients who were unresponsive to conventional therapy were included, and in the remaining 8 studies the included patients were described as having chronic back pain. Patients who had undergone back surgery were excluded in 2 studies17,42 and included in 1 study16; 9 reports did not specify history of back surgery as a study criterion. Treatment settings were conventional health service premises in 11 studies and a dedicated acupuncture clinic in 1.16

Table Graphic Jump LocationTable 2. Details of Randomized Sham-Controlled Trials of Acupuncture for Back Pain*

In 3 studies, conventional acupuncture points were not used: Garvey et al22 and Gunn et al23 inserted needles into trigger points identified by tenderness, and Macdonald et al35 placed needles superficially over trigger points. In the remaining 9 studies, recognized acupuncture points were used. In 9 studies, outcomes were measured only at the end of treatment and in 3 studies there was a follow-up period: Mendelson et al39 and Gunn et al23 used minimum follow-up periods of 8 and 12 weeks, respectively, and Thomas and Lundeberg43 followed up all patients for 6 months.

Table 3 summarizes the quality ratings of all included studies. The range is wide yet the majority of studies scored 3 or more points. The expert acupuncturists held divergent opinions about the adequacy of the treatment in all studies except 1,32 which they agreed was almost totally inadequate.

Table Graphic Jump LocationTable 3. Meta-analysis of Acupuncture for Back Pain: Quality Assessment Scores of Included Studies*
META-ANALYSES

Nine studies presented data in a form suitable for inclusion in the meta-analyses. The results of the primary meta-analysis are presented in Figure 1. A total of 377 patients was included in the trials, and the overall OR was 2.30 (95% CI, 1.28-4.13). There was no significant heterogeneity between studies (χ28=12.58, P>.1).

Place holder to copy figure label and caption
Figure 1.

Meta-analysis of randomized controlled trials of acupuncture for back pain, in descending order of quality.

Graphic Jump Location

In 3 studies16,17,23 the outcome was markedly more positive than in the remainder. These studies have no uniformity of inclusion criteria, acupuncture approach, setting, or end points that could account for the divergence. Alternative (more favorable) outcome data were available in 1 study,17 yielding a new OR for all studies combined (Figure 1) of 2.54 (95% CI, 1.32-4.88).

META-ANALYSES OF SUBGROUPS

The results of the meta-analyses of studies grouped according to design features are given in Figure 2. The OR of the 4 sham-controlled, evaluator-blinded studies17,18,22,39 was 1.37 (95% CI, 0.84-2.25). The results were not meaningfully affected by length of follow-up, quality of acupuncture, type of acupuncture, or number of sessions. There are trends worthy of discussion but CIs of comparisons overlap, indicating that no firm conclusions can be drawn from these data.

Place holder to copy figure label and caption
Figure 2.

Meta-analyses of randomized controlled trials of acupuncture (Acup) for back pain grouped according to common design features. Asterisk indicates patient- and evaluator-blinded design.

Graphic Jump Location
STUDIES EXCLUDED FROM THE META-ANALYSIS

Three studies presented results in a form that was unsuitable for inclusion in this meta-analysis: Macdonald et al35 concluded that acupuncture was significantly superior to control intervention, Yue44 found a positive trend favoring acupuncture, and Gallacchi et al21 showed no superiority of acupuncture over sham acupuncture. The total sample size of these 3 studies was 95. It seems unlikely that the omission of these studies seriously undermines the accuracy of the meta-analyses.

The funnel plot is presented in Figure 3. The studies are not evenly distributed around the combined OR, but there are too few studies to conclude whether publication bias has influenced the result of the meta-analysis.

Place holder to copy figure label and caption
Figure 3.

Funnel plot showing individual odds ratios of randomized controlled trials of acupuncture for back pain against sample size. Continuous line indicates an odds ratio of 1 (no effect); dashed line, combined odds ratios of trials.

Graphic Jump Location

Collectively, these data suggest that acupuncture is an effective treatment for back pain. The assessment of acupuncture for back pain is notoriously difficult for several reasons: there are many variations of acupuncture (eg, points used, method of stimulation) that are not necessarily comparable; back pain is not a distinct entity but an ill-defined category of complaints with diverse causes; acute back pain frequently disappears within days with or without treatment; concomitant treatments abound; and there is no objective, universally accepted outcome measure. The trials included in this analysis are heterogeneous in terms of study population, type of acupuncture used, outcome measure used, and length of follow-up. Thus, it is problematic to form a firm judgment.

Our search strategy was as comprehensive as possible. Yet, it is possible that some trials were not located. In particular, negative trials may not be published.45 We also suspect that complementary medicine journals are heavily biased toward positive results.46 Thus, systematic reviews could easily become distorted. Unfortunately, the present material gives no firm indication for or against the existence of a publication bias and we are unable confidently to exclude this source of error in our analysis.

One inclusion criterion for this analysis was randomization. We, therefore, dealt with trials of relatively high standard. The quality ratings (Table 3) show that the methodological quality was good in the majority of the studies. Only 2 trials, both published in the 1970s, were of low quality. Thus, the present meta-analysis is based largely on rigorous research, which lends weight to its findings.

All the studies recruited patients with chronic pain or who had failed to respond to conventional therapy. Only 2 studies17,43 specifically excluded patients with previous back surgery. Thus, the majority of study participants were associated with a poor prognosis and belonged to a category that is notoriously difficult to treat. The fact that nonetheless the overall result is positive suggests that acupuncture can be helpful even for difficult cases of back pain.

In most studies, the follow-up period was inadequate. Two studies28,43 suggest that the result measured immediately after treatment may be sustained if not improved (Figure 2). Unfortunately, this sample is too small to draw any conclusions, and the long-term effects of acupuncture on back pain remain uncertain. This, it seems, could be a fruitful area of future research.

The subgroup analyses revealed interesting trends. The OR of unblinded studies is larger than that of studies in which blinding had been introduced. This trend might indicate the importance of patient and therapist expectations in terms of clinical outcome and suggests that acupuncture (like most hands-on interventions) is associated with a powerful placebo effect.47 In 2 studies16,32 acupuncture was rated as inadequate, yet tended to be more effective than that judged as adequate. This seems counterintuitive at first glance but might be explained quite easily. In both cases, the descriptions of the acupuncture were minimal. Difficulty in judging the trials was reflected in the large SDs of the experts' scores (Table 3). Thus, the acupuncture technique was poorly described in these reports, but may still have been of good quality. Furthermore, it is relevant to note that both individualizing the selection of points for treatment and repeating the acupuncture more than 4 times were associated with larger effect sizes. The latter trend would be compatible with the dose-response curve of an effective therapy.

In a review of 7 acupuncture trials of acupuncture for pain, including back pain, Deyo48 concluded that "acupuncture is little more effective than placebo therapy which mimics active treatment." Our subgroup analysis of 4 sham-controlled, evaluator-blinded studies yielded a combined OR of 1.37 (95% CI, 0.84-2.25) in favor of genuine acupuncture. Although this finding is not conclusive, it does suggest that further trials are justified to determine whether acupuncture works through specific or nonspecific effects.

It has been suggested that sham acupuncture is an unfair comparison since needling the skin can relieve pain through the process of diffuse noxious inhibitory control.49 This effect can be minimized by needling nonmeridian, nontender points. Future studies should include both sham-control groups and other comparison groups in parallel. The optimal study in acupuncture for back pain should be randomized and fully blinded, with an adequate acupuncture technique and follow-up. It should include a sample size based on power calculation, should evaluate success with a widely accepted outcome measure, and should test acupuncture on a homogeneous subtype of back pain that has previously been suggested to respond favorably. In light of the poor reporting quality of some acupuncture trials (see above), the optimal study should, of course, detail all aspects of the method accurately.

If one accepts that acupuncture is an effective form of treatment for back pain, one might ask about its value compared with other forms of treatment. So far, only exercise treatments,50 transcutaneous electrical nerve stimulation (TENS),51 and spinal manipulation52 have been evaluated in a systematic way. Koes et al50 concluded that it is "uncertain whether exercise is better than other conservative treatments for back pain or whether a specific type of back pain is more effective." The review by Gadsby and Flowerdew51 "provides some evidence to support the use of TENS." Finally, a meta-analysis of spinal manipulation found that it was of short-term benefit.52 The last findings are so convincing that several national guidelines now recommend spinal manipulation as a first-line treatment.53,54 It is interesting, therefore, to see that the overall OR calculated by Shekelle et al52 for all 7 randomized control trials meta-analyzed is similar to the one emerging from this article (OR, 2.0 [95% CI, 1.48-2.77] for spinal manipulation compared with 2.30 [95% CI, 1.28-4.13] for acupuncture). This suggests equal effectiveness for both treatments. However, the usefulness of a therapy is not only determined by effectiveness—safety and costs are other factors. In 2 recent surveys, we found adverse reactions of acupuncture to be considerably less frequent than those of spinal manipulation.55 Unfortunately, no fully conclusive data about the true prevalence of adverse effects for either method exist. This, it seems, is another area of important research for the future. The costs of acupuncture may well be lower than for spinal manipulation: treatment sessions are usually shorter and often less frequent. When 1020 episodes of back pain were investigated, chiropractors had a greater mean number of visits per episode than any other profession,56 which is supported by other data.57 Considering the socioeconomic importance of back pain,2 it would be relevant to establish the relative cost-effectiveness of all major treatments for this condition.

In conclusion, the combined result of all studies shows acupuncture to be superior to various control interventions. The combined results of 4 sham-controlled, evaluator-blinded studies did not show acupuncture to be superior to placebo; further studies are required to conclude with certainty whether acupuncture has specific effects in addition to its nonspecific effects.

Accepted for publication April 13, 1998.

We gratefully acknowledge V. Camp, MD, H. Dyczek, AcM, P. Marcus, MD, R. James, MD, D. Payne, MD, F. Staebler, MD, and A. Ward, MD, for help with aspects of this study.

Corresponding author: Edzard Ernst, MD, PhD, FRCP(Edin), Department of Complementary Medicine, School of Postgraduate Medicine and Health Science, University of Exeter, 25 Victoria Park Rd, Exeter EX2 4NT, England (e-mail: E.Ernst@ex.ac.uk).

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Figures

Place holder to copy figure label and caption
Figure 1.

Meta-analysis of randomized controlled trials of acupuncture for back pain, in descending order of quality.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 2.

Meta-analyses of randomized controlled trials of acupuncture (Acup) for back pain grouped according to common design features. Asterisk indicates patient- and evaluator-blinded design.

Graphic Jump Location
Place holder to copy figure label and caption
Figure 3.

Funnel plot showing individual odds ratios of randomized controlled trials of acupuncture for back pain against sample size. Continuous line indicates an odds ratio of 1 (no effect); dashed line, combined odds ratios of trials.

Graphic Jump Location

Tables

Table Graphic Jump LocationTable 1. Meta-analysis of Acupuncture for Back Pain: Trials Excluded and the Reasons for Exclusion
Table Graphic Jump LocationTable 2. Details of Randomized Sham-Controlled Trials of Acupuncture for Back Pain*
Table Graphic Jump LocationTable 3. Meta-analysis of Acupuncture for Back Pain: Quality Assessment Scores of Included Studies*

References

Frymoyer  JW Back pain and sciatica. N Engl J Med. 1988;318291- 300
Link to Article
Ernst  EFialka  V Idiopathic low back pain: present impact, future directions. Eur J Phys Med Rehabil. 1994;469- 72
Eisenberg  DMKessler  RCFoster  CNorlock  FECalkins  DRDelbanco  TL Unconventional medicine in the United States. N Engl J Med. 1993;328246- 252
Link to Article
Abbot  NCErnst  E Patients' opinions about complementary medicine. Forsch Komplementermed. 1997;4164- 168
Link to Article
Mintel  Not Available Complementary medicines. Market Intelligence Report London, England Mintel1997;
Wadlow  GPeringer  E Retrospective survey of patients of practitioners of traditional Chinese acupuncture in the UK. Comp Ther Med. 1996;41- 7
Link to Article
Han  JTerenius  L Neurochemical basis of acupuncture analgesia. Annu Rev Pharmacol Toxicol. 1982;22192- 220
Link to Article
Filshie  JMorrison  PJ Acupuncture for chronic pain: a review. Palliative Med. 1988;21- 14
Link to Article
Lewith  GT How effective is acupuncture in the management of pain? J R Coll Gen Pract. 1984;34275- 278
Patel  MGutzwiller  FPaccaud  FMarassi  A A meta-analysis of acupuncture for chronic pain. Int J Epidemiol. 1989;18900- 906
Link to Article
Richardson  PHVincent  CA Acupuncture for the treatment of pain: a review of evaluative research. Pain. 1986;2415- 40
Link to Article
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