0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Editor's Correspondence |

First-Generation vs Second-Generation Antihistamines

Yossef Aelony, MD
Arch Intern Med. 1998;158(17):1949-1950. doi:.
Text Size: A A A
Published online

Extract

The article by Kay et al1 confirms in an elegant way that a first-generation antihistamine, diphenhydramine, is sedating and affects performance when given to healthy volunteers, an effect that has been recognized by the medical community and patients for perhaps half a century, and that this does not occur with a second-generation drug, loratadine. Unfortunately, this information is not useful to the clinician for the following reasons: (1) Diphenhydramine is usually prescribed for rhinitis at bedtime, not 4 times per day. (2) Healthy volunteers are not the same as patients with allergic conditions. (3) The attempt to generalize the information to all first-generation antihistamines fails since the authors did not select the least sedating of the first-generation drugs. (4) An advocate for diphenhydramine, a generic drug, would not accept their protocol, whereas an advocate for the second-generation drug would find the protocol ideal.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

First Page Preview

View Large
First page PDF preview

Figures

Tables

References

Correspondence

CME
Also Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
Your answers have been saved for later.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

Articles Related By Topic
Related Collections
PubMed Articles
Chronic urticaria: new management options. World Allergy Organ J 2014;7(1):31.
Atopic cough and fungal allergy. J Thorac Dis 2014;6(Suppl 7):S689-98.
Jobs
brightcove.createExperiences();