Accepted for Publication: August 9, 2014.
Published Online: December 1, 2014. doi:10.1001/jamainternmed.2014.6388.
Study concept and design: Peña, Glynn, Solomon, Ridker.
Acquisition, analysis, or interpretation of data: Peña, Aspberg, MacFadyen, Glynn.
Drafting of the manuscript: Peña, Aspberg.
Critical revision of the manuscript for important intellectual content: Peña, Aspberg, MacFadyen, Glynn, Solomon, Ridker.
Statistical analysis: Peña, Aspberg, Glynn.
Obtained funding: Glynn, Ridker.
Administrative, technical, or material support: Peña, MacFadyen, Ridker.
Study supervision: Ridker.
Conflict of Interest Disclosures: Dr Glynn has received grant support from AstraZeneca through research grants to Brigham and Women’s Hospital for analyses of JUPITER data, as well as investigator-initiated grant support from Novartis. Dr Solomon receives salary support through research grants to Brigham and Women’s Hospital from Amgen, Lilly, Pfizer, and the CORRONA Foundation. He also serves in unpaid roles on trials sponsored by Bristol-Myers Squibb and Pfizer. He receives royalties from UpToDate on chapters regarding nonsteroidal anti-inflammatory drugs and coxibs. He receives an honorarium from the American Orthopaedic Association for serving on a multispecialty board related to their Own the Bone program and is on the Governance Committee of the National Bone Health Alliance. Dr Ridker has received investigator-initiated grant support from the National Heart, Lung, and Blood Institute, Pfizer, AstraZeneca, Novartis, and Amgen; is listed as a coinventor on patents held by the Brigham and Women’s Hospital that relate to inflammatory biomarkers in cardiovascular disease that have been licensed to AstraZeneca and Siemens; and has served as a consultant to Genzyme, Vascular Biogenics, Boston Heart, Amgen, and Isis Pharmaceuticals. No other disclosures are reported.
Funding/Support: The JUPITER trial was supported by AstraZeneca. Dr Peña was supported by grant T32 HL07575 from the National Heart, Lung, and Blood Institute.
Role of the Sponsor: AstraZeneca collected the trial data and monitored study sites but had no role in design of the study protocol; analysis and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.