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Comment & Response |

Risks and Benefits of Antihypertensive Medications in Older Adults

Karen L. Margolis, MD, MPH1; Joshua I. Barzilay, MD2; Ann V. Schwartz, PhD3
[+] Author Affiliations
1HealthPartners Institute for Education and Research, Minneapolis, Minnesota
2Kaiser Permanente of Georgia, Atlanta, Georgia
3University of California, San Francisco
JAMA Intern Med. 2014;174(11):1873. doi:10.1001/jamainternmed.2014.4517.
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To the Editor The recent observational study by Tinetti et al1 reported that treatment with antihypertensive medications is associated with an increased risk of serious fall injuries among community-living older adults with a mean age of 80 years. One reason for this study was to examine a population that may be less healthy than those enrolled in clinical trials and who may have had a higher risk of serious injuries from falls. Approximately 9% of the cohort experienced a serious injury over the follow-up period, most of which were fractures. Although the mean follow-up time is not stated, the annual rate of fractures appears to have been approximately 1.5% to 2.0%.


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November 1, 2014
Mary E. Tinetti, MD; Ling Han, MD, PhD; Gail J. McAvay, PhD
1Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut
JAMA Intern Med. 2014;174(11):1873-1874. doi:10.1001/jamainternmed.2014.4520.
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