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Editor's Correspondence |

More Evidence on Safety of Intramuscular Immune Serum Globulin Produced From Plasma Unscreened for Anti–Hepatitis C Virus Antibodies

Marcello Piazza, MD; Luciano Sagliocca, MD; Grazia Tosone, MD; Raffaele Orlando, MD; Guglielmo Borgia, MD; Filippo Palumbo, MD; Vincenzo Guadagnino, MD; Maria Antonietta Stazi, MSC; Domenico Rosa, PhD; Sergio Abrignani, MD; Aldo Manzin, MD; Massimo Clementi, MD
Arch Intern Med. 1998;158(7):807-808. doi:.
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We are grateful to Cristiano et al for raising the question of the presence of HCV RNA in IG prepared from unscreened plasma. Using reverse transcriptase polymerase chain reaction assays, 2 of the batches (11151 and 12069) used in our trial1 were found to contain viral RNA, while the other 2 (11763 and 11947) did not (A. Weiner, PhD, written communication, November 12, 1997). Although the presence of HCV RNA in IG does not necessarily indicate that the IG is infectious,2 our data represent the first direct evidence that IG positive for HCV RNA from unscreened donors is not infectious.

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Correspondence

April 13, 1998
Marcello Piazza, MD; Luciano Sagliocca, MD; Grazia Tosone, MD; Raffaele Orlando, MD; Guglielmo Borgia, MD; Filippo Palumbo, MD; Vincenzo Guadagnino, MD; Maria Antonietta Stazi, MSC; Domenico Rosa, PhD; Sergio Abrignani, MD; Aldo Manzin, MD; Massimo Clementi, MD
Arch Intern Med. 1998;158(7):807-808. doi:.
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