Accepted for Publication: July 4, 2014.
Published Online: October 6, 2014. doi:10.1001/jamainternmed.2014.4887.
Study concept and design: Garin, Genné, Nendaz, Perneger, Rutschmann, Harbarth, Perrier.
Acquisition, analysis, or interpretation of data: Garin, Carballo, Chuard, Eich, Hugli, Lamy, Nendaz, Petignat, Perneger, Rutschmann, Seravalli, Harbarth, Perrier.
Drafting of the manuscript: Garin, Hugli, Petignat.
Critical revision of the manuscript for important intellectual content: Garin, Genné, Carballo, Chuard, Eich, Hugli, Lamy, Nendaz, Perneger, Rutschmann, Seravalli, Harbarth, Perrier.
Statistical analysis: Garin, Hugli, Perneger, Harbarth, Perrier.
Obtained funding: Garin.
Administrative, technical, or material support: Garin, Genné, Carballo, Hugli, Lamy, Nendaz, Petignat, Seravalli.
Study supervision: Garin, Genné, Carballo, Lamy, Rutschmann, Seravalli.
Conflict of Interest Disclosures: None reported.
Funding/Support: The study was supported by grant 3200BO-120074 from the Swiss National Science Foundation (Dr Perrier) and grants from the Clinical Trial Unit and the Department of Internal Medicine of Geneva University Hospitals (Dr Garin).
Role of the Funder/Sponsor: The funding sources had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and the decision to submit the manuscript for publication.
Additional Contributions: Michelle Le Braz served as the data manager of the trial. We are indebted to all the physicians and nurses who provided study patients: Maryam Ackermann-Zare, MD, Christiane Anex, Gregory Berra, MD, Valentina Bischof, Caroline Brossier, Florence Dartiguenave, Magali Dornier, Yves Flattet, MD, Ute Hornberger, Sophie Levannier, Vincent Poffet, MD, Nora Schwotzer, MD, and Alexis Zawodnik, MD, MPH. Mss Anex, Bischof, Brossier, Dartiguenave, Dornier, Hornberger, and Levannier were employed for the trial and received financial compensation.