Accepted for Publication: June 9, 2014.
Published Online: September 22, 2014. doi:10.1001/jamainternmed.2014.4746.
Study concept and design: Rahimi, Rockey.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Rahimi, Cuthbert, Rockey.
Critical revision of the manuscript for important intellectual content: All authors.
Statistical analysis: Rahimi, Cuthbert, Rockey.
Obtained funding: Rahimi, Rockey.
Administrative, technical, or material support: Rahimi, Rockey.
Study supervision: Rockey.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by National Institutes of Health (NIH) grant 5-T32-DK007745-15 (Rahimi) and NIH National Center for Advancing Translational Sciencesgrant KL2TR000453 (Singal).
Role of the Funder/Sponsor: The funding institutions had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Previous Presentation: This work was presented at the 63rd Annual American Association for the Study of Liver Disease Meeting; November 12, 2012; Boston, Massachusetts.
Additional Contributions: We thank the nurses and hospital staff at Parkland Memorial Hospital for their help in caring for patients in this study. We thank Marlyn Mayo, MD, Lafaine Grant, MD, and William Lee, MD, for participating as members of the DSMB. We thank the University of California, San Diego, for providing us with different versions of the HESA after written permission was granted according to copyright law.