Accepted for Publication: June 28, 2014.
Author Contributions: Drs Sachar and Laine had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Sachar, Laine.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Sachar, Laine.
Critical revision of the manuscript for important intellectual content: Sachar, Vaidya.
Statistical analysis: All authors.
Administrative, technical, or material support: Laine.
Study supervision: Laine.
Published Online: September 8, 2014. doi:10.1001/jamainternmed.2014.4056.
Conflict of Interest Disclosures: Dr Laine reported serving on the data safety monitoring board for a study of a nongastrointestinal investigational drug made by Eisai, which is a manufacturer of PPIs. No other disclosures are reported.
Funding/Support: The study was funded by grant T32 DK007017 from the National Institutes of Health (Dr Sachar).
Role of the Sponsor: The National Institutes of Health had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Previous Presentation: This study was presented as an abstract at Digestive Disease Week; May 4, 2014; Chicago, Illinois.