Muscle pain, fatigue, and weakness are common adverse effects of statin medications and may decrease physical activity in older men. In a prospective cohort study of community-dwelling men 65 years and older from the Osteoporotic Fractures in Men Study, Lee and coauthors studied the cross-sectional and longitudinal association between statin use and physical activity. Physical activity was measured by a validated self-administered questionnaire at baseline, 4.6 years, and 6.9 years (n = 3039). At the last follow-up visit, physical activity was also measured by an accelerometer worn by the participants (n = 3079). They found that statin use was associated with modestly less physical activity, even after accounting for medical history and other potentially confounding factors. In an Invited Commentary, Golomb sets the findings in clinical context.