Accepted for Publication: March 26, 2014.
Published Online: June 30, 2014. doi:10.1001/jamainternmed.2014.2556.
Author Contributions: Drs Anderson and Stein had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.
Study concept and design: Liebschutz, Stein.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Liebschutz, Anderson, Dossabhoy, Stein.
Critical revision of the manuscript for important intellectual content: Liebschutz, Crooks, Herman, Anderson, Tsui, Meshesha, Stein.
Statistical analysis: Anderson.
Obtained funding: Stein.
Administrative, technical, or material support: Liebschutz, Crooks, Herman, Meshesha, Dossabhoy, Stein.
Study supervision: Liebschutz, Herman, Stein.
Conflict of Interest Disclosures: None reported.
Funding/Support: This study was supported by grant R01 DA026223 (Dr Stein) and award K24 DA000512 (Dr Stein) from the National Institute on Drug Abuse.
Role of the Sponsor: The National Institute on Drug Abuse had no role in design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Previous Presentations: The results of this study were presented at the Society of General Internal Medicine Annual Meeting; April 24, 2013; Denver, Colorado; and the College on Problems of Drug Dependence Annual Meeting; June 20, 2013; San Diego, California.
Additional Contributions: Reckitt Benckiser Pharmaceuticals provided the study medication and reviewed the manuscript for scientific accuracy. Contributions to the research were made by Joel Hoyte, MD, Meredith Collins, MPH, Sam Masur, BA, Donna Beers, RN, Colleen Labelle, RN, and the physician, nursing, and pharmacy staffs at Boston Medical Center and the office-based opioid treatment program. Dr Hoyte, Ms Collins, Mr Masur, and Ms Beers were compensated for their work.