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Comment & Response |

Gabapentin Treatment for Alcohol Dependence—Reply

Barbara J. Mason, PhD1; Vivian Goodell, MPH1; Farhad Shadan, MD, PhD1,2
[+] Author Affiliations
1The Scripps Research Institute, Pearson Center for Alcoholism and Addiction, Research, La Jolla, California
2Scripps Clinic and Scripps Green Hospital, La Jolla, California
JAMA Intern Med. 2014;174(7):1201-1202. doi:10.1001/jamainternmed.2014.1591.
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In Reply We are delighted to learn of Geisler and Ghosh’s interest in treating alcohol dependence and welcome the opportunity to address some of their misunderstandings about our report of a randomized clinical trial of gabapentin for the treatment of alcohol dependence.1 Contrary to their concern that ours was initially a 2-arm trial, our original protocol in fact specified a 3-arm dose-ranging design (gabapentin, 1800, 900, and 0 mg/d) and was reviewed as such by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), the Scripps institutional review board, and the JAMA Internal Medicine (JAMA-IM) statistical reviewer (per JAMA-IM’s requirement that the original protocol be included with a clinical trial submission), and the clinicaltrials.gov link referenced by the authors specifies “dose ranging.”

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July 1, 2014
Benjamin P. Geisler, MD, MPH; Arnab Ghosh, MD, MA
1Department of Medicine, NYU School of Medicine, New York, New York
JAMA Intern Med. 2014;174(7):1201. doi:10.1001/jamainternmed.2014.1618.
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