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Comment & Response |

Estimating Overdiagnosis in Lung Cancer Screening

Sébastien Couraud, MD, MSc1,2; Laurent Greillier, MD, PhD3; Bernard Milleron, MD4,5 ; for the IFCT Lung Cancer Screening Group
[+] Author Affiliations
1Service de Pneumologie Aiguë Spécialisée et Cancérologie Thoracique, CH Lyon Sud, Hospices Civils de Lyon, Pierre Bénite, France
2Faculté de Médecine Lyon-Sud, Université Lyon 1, Oullins, France
3Aix Marseille Univ–Assistance Publique–Hôpitaux de Marseille, Multidisciplinary Oncology & Therapeutic Innovations Department, Marseille, France
4Respiratory Disease Department, Tenon Hospital, Assistance Publique–Hôpitaux de Paris, Paris, France
5Intergroupe Francophone de Cancérologie Thoracique (IFCT), Paris, France
JAMA Intern Med. 2014;174(7):1197. doi:10.1001/jamainternmed.2014.1532.
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To the Editor We read with interest the article by Patz et al1 investigating overdiagnosis in the National Lung Screening Trial (NLST). In their investigation, the authors found the upper bound for probability of overdiagnosis to be 11.0% to 18.5% for all lung cancers and even higher for bronchioloalveolar carcinoma (BAC) (67.6% to 78.9%). However, this risk assessment did not consider the lead- and the length-time biases.2


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July 1, 2014
Edward F. Patz Jr, MD; Paul Pinsky, PhD; Barnett S. Kramer, MD
1Department of Radiology, Duke University Medical Center, Durham, North Carolina
2National Cancer Institute, Bethesda, Maryland
JAMA Intern Med. 2014;174(7):1198-1199. doi:10.1001/jamainternmed.2014.1525.
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