0
We're unable to sign you in at this time. Please try again in a few minutes.
Retry
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
Retry
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Evidence to Practice |

The Comparative Clinical Effectiveness and Value of Simeprevir and Sofosbuvir for Chronic Hepatitis C Virus Infection

Daniel A. Ollendorf, MPH1; Jeffrey A. Tice, MD2; Steven D. Pearson, MD, MSc1
[+] Author Affiliations
1Institute for Clinical and Economic Review, Boston, Massachusetts
2Division of General Internal Medicine, Department of Medicine, University of California, San Francisco
JAMA Intern Med. 2014;174(7):1170-1171. doi:10.1001/jamainternmed.2014.2151.
Text Size: A A A
Published online

Extract

Hepatitis C virus (HCV) infection affects 3 to 4 million people in the United States and is a major cause of liver failure, hepatocellular carcinoma, and liver transplantation.1 Prior to 2011, the combination of pegylated interferon and ribavirin was the best available therapy for HCV. When treated with this combination of medicines, approximately half of patients with genotype 1 disease, the most prevalent type of HCV in the United States, clear the virus from their bloodstream and achieve a sustained virologic response that greatly reduces their risk of progressive liver disease. However, pegylated interferon and ribavirin require a year of therapy and often produce substantial adverse effects that reduce adherence; in addition, many patients are not eligible for this therapy because of medical or psychiatric comorbidities.2 In 2011, introduction of the first-generation, direct-acting antiviral drugs boceprevir (Victrelis; Merck & Co) and telaprevir (Incivek; Vertex Pharmaceuticals Inc) substantially improved rates of sustained virologic response when used in combination with pegylated interferon and ribavirin to treat patients with genotype 1 infections. This improvement brought new challenges, however, including additional adverse effects, stringent dosing requirements, and high pill burdens.3

Figures in this Article

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview

Figures

Place holder to copy figure label and caption
Figure.
Total Budgetary Impact and Potential Cost Offsets From Use of Newer Drug Regimens in the Population With Chronic Hepatitis C Virus in California

Fifty percent of infected patients are treated (n = 270 525).

Graphic Jump Location

Tables

References

Correspondence

CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Collections
PubMed Articles
Jobs
brightcove.createExperiences();