Accepted for Publication: January 31, 2014.
Published Online: March 31, 2014. doi:10.1001/jamainternmed.2014.511.
Study concept and design: Reimers, Bastiaannet, van Vlierberghe, Fodde, Kuppen, Morreau, Liefers.
Acquisition, analysis, or interpretation of data: All authors.
Drafting of the manuscript: Reimers, Bastiaannet, Langley, van Eijk, Lemmens, Kuppen, Liefers.
Critical revision of the manuscript for important intellectual content: Reimers, Bastiaannet, van Vlierberghe, Lemmens, van Herk-Sukel, van Wezel, Fodde, Kuppen, Morreau, van de Velde, Liefers.
Statistical analysis: Reimers, Bastiaannet, van Herk-Sukel.
Obtained funding: Kuppen, Liefers.
Administrative, technical, or material support: Reimers, van Eijk, van Vlierberghe, Lemmens, van Herk-Sukel, Morreau.
Study supervision: Reimers, Fodde, Kuppen, Morreau, van de Velde, Liefers.
Conflict of Interest Disclosures: Dr van Herk-Sukel is an employee of the PHARMO Institute. This independent research institute performs financially supported studies for government and related health care authorities and several pharmaceutical companies. The present study, however, was not supported by a pharmaceutical company. Dr Langley has received a honorarium from the Aspirin Foundation and is a consultant for Bayer. No other disclosures were reported.
Funding/Support: This work was supported by an unrestricted grant from the Sloos-Alandt family (Dr Liefers).
Role of the Sponsor: The sponsor had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.
Additional Contributions: We thank the pathologists in all participating hospitals for their cooperation and in providing study material.