Group Information: The AREDS2 Research Group members are listed in eAppendix 1 in the Supplement.
Accepted for Publication: January 8, 2014.
Published Online: March 17, 2014. doi:10.1001/jamainternmed.2014.328.
Study concept and design: Bonds, Eaton, Clemons, Fine, Chew.
Acquisition, analysis, or interpretation of data: Bonds, Harrington, Worrall, Bertoni, Hsia, Robinson, Clemons, Fine, Chew.
Drafting of the manuscript: Bonds, Harrington, Chew.
Critical revision of the manuscript for important intellectual content: Worrall, Bertoni, Eaton, Hsia, Robinson, Clemons, Fine.
Statistical analysis: Harrington, Clemons.
Obtained funding: Fine, Chew.
Administrative, technical, or material support: Bonds, Worrall, Hsia, Fine.
Study supervision: Worrall, Clemons, Fine, Chew.
AREDS2 Research Group: The AREDS2 Research Group members are listed in eAppendix 1 in the Supplement.
Conflict of Interest Disclosures: Dr Worrall is an Associate Editor of the journal Neurology. Dr Hsia is employed by and owns stock in AstraZeneca. Dr Robinson has received institutional research grants from Amarin, Amgen, Daiichi-Sankyo, Esperion, Genentech/Hoffmann La Roche, Glaxo-Smith Kline, Merck. No other disclosures are reported.
Funding/Support: The AREDS2 study is supported by the intramural program funds and contracts from the National Eye Institute/National Institutes of Health, Department of Health and Human Services (contract No. HHS-N-260-2005-00007-C and ADB contract No. N01-EY-5-0007). Funds were generously contributed to these contracts by the following National Institutes of Health (NIH): Office of Dietary Supplements, National Center for Complementary and Alternative Medicine, National Institute on Aging, National Heart, Lung, and Blood Institute, and National Institute of Neurological Disorders and Stroke.
Role of the Sponsors: Drs Bonds, Fine, and Chew are employed by the NIH. The individuals at NIH who made the funding decisions were not the same as who designed or wrote the manuscript. Drs Bonds, Fine, and Chew had a direct role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication; however, no other individual at NIH was involved in these roles.
Additional Information: The full study protocol is available at http://www.areds2.org.