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Comment & Response |

Statins and Musculoskeletal Adverse Events—Reply

Ishak Mansi, MD1,2; Eric M. Mortensen, MD, MSc1,2; Christopher R. Frei, PharmD, MSc3,4
[+] Author Affiliations
1VA North Texas Health Care System, University of Texas Southwestern Medical Center, Dallas
2Department of Internal Medicine and Clinical Sciences, University of Texas Southwestern Medical Center, Dallas
3College of Pharmacy, The University of Texas at Austin, Austin
4Pharmacotherapy Education and Research Center, School of Medicine, University of Texas Health Science Center, San Antonio
JAMA Intern Med. 2014;174(2):303-304. doi:10.1001/jamainternmed.2013.12683.
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In Reply Dr Finkelstein argues that the increase in odds ratios (ORs) of musculoskeletal diseases in statin users may be attributable to imperfect propensity score matching. In addition to the propensity score–matched cohort, we examined the risk of outcomes in different cohorts (Table 2 of our article)1 including a whole population cohort, a no-comorbidity index cohort, a musculoskeletal incident cohort, and a 2-year statin cohort. Each of these cohorts included different populations who varied in baseline characteristics. We also used different definitions for musculoskeletal outcomes. Our results remained consistent throughout.


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February 1, 2014
Murray M. Finkelstein, PhD, MD
1Department of Family and Community Medicine, University of Toronto, Toronto, Ontario, Canada
JAMA Intern Med. 2014;174(2):302. doi:10.1001/jamainternmed.2013.12697.
February 1, 2014
Mitchell H. Katz, MD; Rita F. Redberg, MD, MSc
1Department of Health Services, Los Angeles County, Los Angeles, California
2Department of Medicine, University of California, San Francisco
JAMA Intern Med. 2014;174(2):302-303. doi:10.1001/jamainternmed.2013.12682.
February 1, 2014
Rene Baudrand, MD; Gordon H. Williams, MD
1Department of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
JAMA Intern Med. 2014;174(2):302. doi:10.1001/jamainternmed.2013.12705.
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