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Comment & Response |

Statins and Musculoskeletal Adverse Events

Rene Baudrand, MD1; Gordon H. Williams, MD1
[+] Author Affiliations
1Department of Endocrinology, Diabetes, and Hypertension, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts
JAMA Intern Med. 2014;174(2):302. doi:10.1001/jamainternmed.2013.12705.
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To the Editor We read with interest the study of Mansi et al1 that reported a higher likelihood of musculoskeletal adverse events among statin users.1 Strengths of this retrospective study are the propensity-scored and subsequent analysis, the complete follow-up, and the access to the same health care system. Surprisingly, the authors reported a high rate of musculoskeletal diseases during follow-up (both groups >80%), with a small but significant difference toward statin users. These unusual rates could be related to the type of the population (mainly active-duty soldiers and veterans) and/or the use of International Classification of Diseases, Ninth Revision, Clinical Modification codes that lack specificity and do not inform on the severity of the symptoms nor the need to stop therapy.


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February 1, 2014
Mitchell H. Katz, MD; Rita F. Redberg, MD, MSc
1Department of Health Services, Los Angeles County, Los Angeles, California
2Department of Medicine, University of California, San Francisco
JAMA Intern Med. 2014;174(2):302-303. doi:10.1001/jamainternmed.2013.12682.
February 1, 2014
Ishak Mansi, MD; Eric M. Mortensen, MD, MSc; Christopher R. Frei, PharmD, MSc
1VA North Texas Health Care System, University of Texas Southwestern Medical Center, Dallas2Department of Internal Medicine and Clinical Sciences, University of Texas Southwestern Medical Center, Dallas
3College of Pharmacy, The University of Texas at Austin, Austin4Pharmacotherapy Education and Research Center, School of Medicine, University of Texas Health Science Center, San Antonio
JAMA Intern Med. 2014;174(2):303-304. doi:10.1001/jamainternmed.2013.12683.
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