Accepted for Publication: November 16, 2013.
Published Online: January 20, 2014. doi:10.1001/jamainternmed.2013.13957.
Study concept and design: Clark, Delate, Riggs, Witt, Hylek, Ageno, Dentali, Crowther.
Acquisition of data: Clark, Delate, Riggs.
Analysis and interpretation of data: Delate, Witt, Hylek, Garcia, Ageno, Crowther.
Drafting of the manuscript: Clark, Delate, Riggs, Witt, Dentali, Crowther.
Critical revision of the manuscript for important intellectual content: Clark, Delate, Riggs, Witt, Hylek, Garcia, Ageno, Dentali.
Statistical analysis: Delate, Riggs, Witt, Hylek.
Administrative, technical, or material support: Clark, Garcia.
Study supervision: Clark, Ageno, Crowther.
Conflict of Interest Disclosures: Dr Crowther serves as an advisor to Alexion, Artisan Pharma, Bayer, Boehringer Ingelheim, CSL Behring, Leo Pharma, and Pfizer; has prepared educational materials for CSL Behring, Octapharm, and Pfizer; and has provided expert testimony for Bayer. Dr Crowther’s institution has received funding for research projects from Boehringer Ingelheim, Leo Pharma, Octapharm, Pfizer. Dr Hylek serves as an advisor to Bayer, Boehringer Ingelheim, Bristol-Myers Squibb, Daiichi Sankyo, Johnson and Johnson, and Pfizer and participates in clinical symposia sponsored by Bayer, Boehringer Ingelheim, and Bristol-Myers Squibb. Dr Garcia served as an advisor to Boehringer Ingelheim, Bristol-Meyers Squibb, CSL Behring, and Daiichi Sankyo. No other disclosures were reported.