Comment & Response |

Phenytoin Toxicity Unlikely to Result in Arrhythmias—Reply

Colleen J. Johnson, MD, MS1; Mintu P. Turakhia, MD, MAS2,3
[+] Author Affiliations
1Department of Medicine (Heart and Vascular Institute), Tulane University, New Orleans, Louisiana
2Veterans Affairs Palo Alto Health Care System, Palo Alto, California
3Department of Medicine (Cardiovascular Medicine), Stanford University, Stanford, California
JAMA Intern Med. 2014;174(1):167-168. doi:10.1001/jamainternmed.2013.11168.
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In Reply We appreciate the comments provided by Algren and Christian, who contend that phenytoin did not contribute to our presented clinical findings.1

We disagree and are certain that phenytoin use was a major contributor. The classic findings of high-dose, rapid phenytoin administration that they describe are inapplicable to our patient, who was a complex patient with recent liver transplant, status epilepticus, and renal failure, in whom polypharmacy resulted in the electrocardiographic (ECG) changes.


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January 1, 2014
D. Adam Algren, MD; Michael R. Christian, MD
1Department of Emergency Medicine, Truman Medical Center/Children’s Mercy Hospital, University of Missouri–Kansas City School of Medicine, Kansas City2Department of Pediatrics, Truman Medical Center/Children’s Mercy Hospital, University of Missouri–Kansas City School of Medicine, Kansas City
JAMA Intern Med. 2014;174(1):167. doi:10.1001/jamainternmed.2013.11177.
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