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Understanding Drug Effects in Older People: The Role of Pharmacology

Danijela Gnjidic, PhD, MPH1; Nicholas Wilson, PhD2; Sarah N. Hilmer, MBBS, PhD3
[+] Author Affiliations
1Faculty of Pharmacy, University of Sydney, Sydney, New South Wales, Australia
2Department of Rheumatology, Mafraq Hospital, Abu Dhabi, United Arab Emirates
3Royal North Shore Hospital, Kolling Institute of Medical Research and Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia
JAMA Intern Med. 2013;173(20):1930. doi:10.1001/jamainternmed.2013.9782.
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To the Editor We read with interest the article by Berry et al,1 which reported that nursing home residents exposed to nonbenzodiazepine hypnotic drugs had an increased risk for hip fracture. These findings are not surprising considering the pharmacologic actions of this drug class and are consistent with previous studies that have demonstrated clinically significant harms from sedative drug use in older people residing in nursing homes.2,3


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November 11, 2013
Sarah D. Berry, MD, MPH; David D. Dore, PharmD, PhD
1Institute for Aging Research, Hebrew SeniorLife and Harvard Medical School, Boston, Massachusetts
2Department of Health Services, Policy and Practice and Center for Gerontology and Health Care Research, Brown University, Providence, Rhode Island
JAMA Intern Med. 2013;173(20):1930-1931. doi:10.1001/jamainternmed.2013.9762.
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