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Comment & Response |

Dietary and Supplemental Calcium Intake and Mortality—Reply

Qian Xiao, PhD1; Yikyung Park, ScD1
[+] Author Affiliations
1Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, Rockville, Maryland
JAMA Intern Med. 2013;173(19):1841-1842. doi:10.1001/jamainternmed.2013.9232.
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In Reply In their study of a Hong Kong Chinese population, whose calcium intake is substantially lower than the Western population, Chan et al reported there was a protective effect of dietary calcium intake on total mortality and cardiovascular mortality. The lower cutoff of their highest intake category (>762 mg/d for men and >668 mg/d for women) are around the median intake values (739 mg/d for men and 648 mg/d for women) found in our US cohort. As shown in Figure 2 of our article,1 we observed a nonlinear association between total calcium intake and total cardiovascular disease mortality in men: risk decreased at a calcium intake up to approximately 1200 mg/d, but started to increase at an intake of 1500 mg/d and higher. Therefore, a study with population that has relatively low calcium intake and narrow range of intake is likely to observe an inverse association between calcium intake and mortality, especially cardiovascular disease mortality.


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October 28, 2013
Elke Theuwissen, PhD; Vladimir Badmaev, MD, PhD; Cees Vermeer, PhD
1VitaK, Maastricht University, the Netherlands
2NattoPharma ASA, Oslo, Norway
JAMA Intern Med. 2013;173(19):1841. doi:10.1001/jamainternmed.2013.9260.
October 28, 2013
Robert Colgrove, MD
1Division of Infectious Diseases, Mount Auburn Hospital, Cambridge, Massachusetts
JAMA Intern Med. 2013;173(19):1840. doi:10.1001/jamainternmed.2013.9267.
October 28, 2013
Ruth Chan, PhD; Jason Leung, MSc; Jean Woo, MD
1Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong Special Administrative Region
2Jockey Club Centre for Osteoporosis Care and Control, The Chinese University of Hong Kong, Hong Kong Special Administrative Region
JAMA Intern Med. 2013;173(19):1840. doi:10.1001/jamainternmed.2013.9276.
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