0
Comment & Response |

Dietary and Supplemental Calcium Intake and Mortality

Elke Theuwissen, PhD1; Vladimir Badmaev, MD, PhD2; Cees Vermeer, PhD1
[+] Author Affiliations
1VitaK, Maastricht University, the Netherlands
2NattoPharma ASA, Oslo, Norway
JAMA Intern Med. 2013;173(19):1841. doi:10.1001/jamainternmed.2013.9260.
Text Size: A A A
Published online

Extract

To the Editor In a recent report, Xiao et al1 discuss the outcome of the National Institutes of Health (NIH)–AARP Diet and Health Study, which evaluated the role of calcium intake on cardiovascular health. The outcome of the study revealed that intake of 1000 mg/d of supplemental calcium was associated with significant increase in cardiovascular mortality in men but not in women.

Arterial calcification is an actively regulated process with a key function for the vitamin K–dependent matrix Gla protein (MGP).2 Mature MGP is a powerful inhibitor of soft-tissue calcification and is abundantly expressed by vascular smooth muscle cells. The vitamin K–dependent step in MGP synthesis is the carboxylation of 5 glutamate residues into γ-carboxyglutamate (Gla), which are essential for MGP’s calcification inhibitory activity. In healthy adults, at least 20% of plasma MGP occurs in the uncarboxylated, inactive form. Conformation-specific assays have demonstrated that circulating uncarboxylated MGP has a high predictive value for cardiovascular and overall mortality.2,3 Moreover, several independent population-based studies have shown that dietary vitamin K2 intake is inversely associated with cardiovascular disease and mortality.

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

October 28, 2013
Qian Xiao, PhD; Yikyung Park, ScD
1Division of Cancer Epidemiology and Genetics, Nutritional Epidemiology Branch, National Cancer Institute, Rockville, Maryland
JAMA Intern Med. 2013;173(19):1841-1842. doi:10.1001/jamainternmed.2013.9232.
CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Jobs
brightcove.createExperiences();