Comment & Response |

Glucagon-like Peptide 1–Based Drugs and Pancreatic Safety

Emanuel Raschi, MD, PhD1; Carlo Piccinni, PharmD, PhD1; Giulio Marchesini, MD, PhD1
[+] Author Affiliations
1Department of Medical and Surgical Sciences, University of Bologna, Bologna, Italy
JAMA Intern Med. 2013;173(19):1843. doi:10.1001/jamainternmed.2013.8150.
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To the Editor More than 4 years after the first description of exenatide-related pancreatitis, the recent study by Singh et al1 reports a 2-fold increased risk of hospital admission for acute pancreatitis with glucagon-like peptide 1 (GLP-1) mimetics, compared with other antidiabetics.1 The study has immediately fuelled the debate on this topic,2 but a different design is definitely needed to fully elucidate this issue in a more comprehensive clinical perspective.


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October 28, 2013
Sonal Singh, MD, MPH
1Department of Medicine and the Center for Public Health and Human Rights, Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland
JAMA Intern Med. 2013;173(19):1843-1844. doi:10.1001/jamainternmed.2013.8128.
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