0
Comment & Response |

Glucagon-like Peptide 1–Based Drugs and Pancreatic Safety

Kimberly G. Brodovicz, DrPH1; Samuel S. Engel, MD1; Nancy A. Thornberry, BS1
[+] Author Affiliations
1Merck Sharp & Dohme Corporation, Whitehouse Station, New Jersey
JAMA Intern Med. 2013;173(19):1842-1843. doi:10.1001/jamainternmed.2013.8138.
Text Size: A A A
Published online

Extract

To the Editor We would like to highlight important methodological limitations to the case-control study by Singh et al,1 in which the authors investigated whether an association might exist between acute pancreatitis and use of glucagon-like peptide 1 (GLP-1)–based therapies in patients with type 2 diabetes mellitus using an insurance claims database.

The use of claims databases to create control populations and adjust for confounders is limited by the absence of data on relevant baseline characteristics. In Singh et al,1 the control population was developed using demographic and diabetes-related factors but not factors associated with risk of developing pancreatitis. Prevalence rates of risk factors for pancreatitis such as obesity, hypertriglyceridemia, and alcohol use are typically underestimated in claims databases, such that residual confounding likely persists despite attempts to adjust for these factors. Pancreatitis diagnoses were not confirmed through medical chart review but were based on an algorithm with positive predictive value stated as 60% to 80%.1

Topics

Sign In to Access Full Content

Don't have Access?

Register and get free email Table of Contents alerts, saved searches, PowerPoint downloads, CME quizzes, and more

Subscribe for full-text access to content from 1998 forward and a host of useful features

Activate your current subscription (AMA members and current subscribers)

Purchase Online Access to this article for 24 hours

First Page Preview

View Large
/>
First page PDF preview

Figures

Tables

References

Correspondence

October 28, 2013
Sonal Singh, MD, MPH
1Department of Medicine and the Center for Public Health and Human Rights, Johns Hopkins University Schools of Medicine and Public Health, Baltimore, Maryland
JAMA Intern Med. 2013;173(19):1843-1844. doi:10.1001/jamainternmed.2013.8128.
CME
Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
NOTE:
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment

Multimedia

Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 1

Sign In to Access Full Content

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Jobs
brightcove.createExperiences();