We're unable to sign you in at this time. Please try again in a few minutes.
We were able to sign you in, but your subscription(s) could not be found. Please try again in a few minutes.
There may be a problem with your account. Please contact the AMA Service Center to resolve this issue.
Contact the AMA Service Center:
Telephone: 1 (800) 262-2350 or 1 (312) 670-7827  *   Email: subscriptions@jamanetwork.com
Error Message ......
Research Letter |

Risk and Risk Reduction of Major Coronary Events Associated With Contemporary Breast Radiotherapy

David J. Brenner, PhD, DSc1; Igor Shuryak, MD1; Gabor Jozsef, PhD2; Keith J. DeWyngaert, PhD2; Silvia C. Formenti, MD2
[+] Author Affiliations
1Center for Radiological Research, Columbia University Medical Center, New York, New York
2Department of Radiation Oncology, New York University School of Medicine, New York
JAMA Intern Med. 2014;174(1):158-160. doi:10.1001/jamainternmed.2013.11790.
Text Size: A A A
Published online


Long-term breast cancer survival rates have improved markedly over recent decades, so minimization of long-term treatment-related complications is increasingly important. Several reports have suggested links between breast cancer radiotherapy and long-term cardiovascular mortality.1 A recent analysis by Darby et al2 of patients treated with breast radiotherapy between 1958 and 2001 revealed a statistically significant linear dependence of the risk of major coronary events on mean cardiac dose. We use these historical data to estimate risks of major coronary events induced by modern breast radiotherapy. Our motivation is to quantify contemporary risks and also to guide efforts to minimize radiotherapy-induced cardiovascular risks.

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

First Page Preview

View Large
First page PDF preview





Meets CME requirements for:
Browse CME for all U.S. States
Accreditation Information
The American Medical Association is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The AMA designates this journal-based CME activity for a maximum of 1 AMA PRA Category 1 CreditTM per course. Physicians should claim only the credit commensurate with the extent of their participation in the activity. Physicians who complete the CME course and score at least 80% correct on the quiz are eligible for AMA PRA Category 1 CreditTM.
Note: You must get at least of the answers correct to pass this quiz.
You have not filled in all the answers to complete this quiz
The following questions were not answered:
Sorry, you have unsuccessfully completed this CME quiz with a score of
The following questions were not answered correctly:
Commitment to Change (optional):
Indicate what change(s) you will implement in your practice, if any, based on this CME course.
Your quiz results:
The filled radio buttons indicate your responses. The preferred responses are highlighted
For CME Course: A Proposed Model for Initial Assessment and Management of Acute Heart Failure Syndromes
Indicate what changes(s) you will implement in your practice, if any, based on this CME course.
Citing articles are presented as examples only. In non-demo SCM6 implementation, integration with CrossRef’s "Cited By" API will populate this tab (http://www.crossref.org/citedby.html).
Submit a Comment


Some tools below are only available to our subscribers or users with an online account.

Web of Science® Times Cited: 1

Sign in

Create a free personal account to sign up for alerts, share articles, and more.

Purchase Options

• Buy this article
• Subscribe to the journal

Related Content

Customize your page view by dragging & repositioning the boxes below.

See Also...
Articles Related By Topic
Related Topics
PubMed Articles
PSMD9 expression predicts radiotherapy response in breast cancer. Mol Cancer Published online Mar 28, 2014.;
Radiotherapy Issues in Elderly Breast Cancer Patients. Breast Care (Basel) 2012;7(6):453-459.

Users' Guides to the Medical Literature
Chapter 7. Does Treatment Lower Risk? Understanding the Results

Users' Guides to the Medical Literature
Odds vs Risks