Accepted for Publication: May 28, 2013.
Published Online: August 12, 2013. doi:10.1001/jamainternmed.2013.9043.
Acquisition of data: Witham, Price, Struthers, Donnan, Ford, McMurdo.
Analysis and interpretation of data: Witham, Struthers, Donnan, Messow, Ford, McMurdo.
Critical revision of the manuscript for important intellectual content: All authors.
Administrative, technical, and material support: All authors.
Conflict of Interest Disclosures: Dr Witham was funded by a Chief Scientist Office Clinician Scientist Fellowship. We also acknowledge the financial support of National Health Service Research Scotland through National Health Service Tayside in facilitating this research.
Funding/Support: This clinical trial was funded by the Chief Scientist Office, Scottish Government, grant CZH/4/470. The trial sponsor was the University of Dundee.
Role of the Sponsors: Neither the sponsor nor the funder had influence over the analysis, interpretation of the data, or preparation, review, or approval of the manuscript. Both the funder and the sponsor contributed to the design and conduct of the study, data collection, and data management.
Additional Contributions: Lesley McFarlane, BSc (University of Dundee), performed laboratory analyses, the Scottish Primary Care Research Network and Tayside Clinical Research Centre provided recruitment assistance, and Valona Gouck (University of Dundee) provided secretarial support.